Publication: Estudio de la degradación de esteroides en Novosphingobium tardaugens NBRC 16725 y sus aplicaciones biotecnológicas
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2022-06
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Universidad Complutense de Madrid
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Abstract
Los esteroides son compuestos que presentan una gran distribución en la naturaleza, estando involucrados en diversas funciones biológicas y cuya estructura química los hace especialmente recalcitrantes a la degradación microbiana. Los esteroides tienen relevancia por su implicación en enfermedades infecciosas como la tuberculosis, por encontrarse entre los medicamentos más producidos por la industria farmacéutica y porque su presencia en el entorno natural puede suponer un riesgo medio ambiental. En los últimos años la contaminación ambiental producida por compuestos disruptores endocrinos (EDCs) ha recibido gran atención, ya que son sustancias capaces de afectar la salud a nivel sistémico y cuya ubicuidad supone un riesgo a nivel global. Dentro de estos compuestos destacan los estrógenos, un tipo de hormonas esteroideas, por su alta toxicidad a bajas concentraciones y su creciente presencia en diferentes nichos ecológicos. Aunque se ha propuesto la degradación microbiana como un método eficaz para eliminar estos compuestos, no se conocen en detalle la genética ni la bioquímica implicada en estos procesos. Las bacterias de la familia Sphingomonadaceae, caracterizadas por su capacidad de metabolizar diferentes compuestos contaminantes, son candidatos interesantes para estudiar la degradación de estrógenos, sin embargo, la dificultad para producir modificaciones genéticas en las cepas descritas dificulta esta tarea...
Steroids are widely distributed in nature, being involved in various biological functions and their chemical structure makes them particularly resistant to microbial degradation. Steroids are relevant because of their involvement in infectious diseases such as tuberculosis, because they are among the most produced drugs by the pharmaceutical industry and because their presence in the natural environment can pose an environmental risk.In recent years, environmental pollution caused by endocrine disrupting chemicals (EDCs) has received great attention, as they are capable of affecting health at a systemic level and their ubiquity poses a global risk. Among these compounds, estrogens, a type of steroid hormones, stand out for their high toxicity at low concentrations and their increasing presence in different ecological niches. Although microbial degradation has been proposed as an effective method to eliminate these compounds, the genetics and biochemistry involved in these processes are not known in detail. Bacteria of the family Sphingomonadaceae, characterized by their ability to metabolize different contaminant compounds, are interesting candidates for studying estrogen degradation; however, the difficulty in producing genetic modifications in the described strains hinders this task...
Steroids are widely distributed in nature, being involved in various biological functions and their chemical structure makes them particularly resistant to microbial degradation. Steroids are relevant because of their involvement in infectious diseases such as tuberculosis, because they are among the most produced drugs by the pharmaceutical industry and because their presence in the natural environment can pose an environmental risk.In recent years, environmental pollution caused by endocrine disrupting chemicals (EDCs) has received great attention, as they are capable of affecting health at a systemic level and their ubiquity poses a global risk. Among these compounds, estrogens, a type of steroid hormones, stand out for their high toxicity at low concentrations and their increasing presence in different ecological niches. Although microbial degradation has been proposed as an effective method to eliminate these compounds, the genetics and biochemistry involved in these processes are not known in detail. Bacteria of the family Sphingomonadaceae, characterized by their ability to metabolize different contaminant compounds, are interesting candidates for studying estrogen degradation; however, the difficulty in producing genetic modifications in the described strains hinders this task...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Químicas, leída el 01-03-2022