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The therapeutic potential of fungal ribotoxins



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Carreras Sangrà, Nelson y Álvarez García, Elisa y Herrero Galán, Elías y Tomé, Jaime y Lacadena, Javier y Alegre Cebollada, Jorge y Oñaderra, Mercedes y Gavilanes, José G. y Martínez del Pozo, Álvaro (2008) The therapeutic potential of fungal ribotoxins. Current Pharmaceutical Biotechnology, 9 . pp. 153-160. ISSN 1389-2010

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Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific activity on a
conserved region of the larger molecule of rRNA, known as the sarcin–ricin loop. This cleavage of a single phosphodiester
bond inactivates the ribosome and leads to protein synthesis inhibition and cell death. In addition to this ribonucleolytic
activity, ribotoxins can cross lipid membranes in the absence of any known protein receptor. This ability is due
to their capacity to interact with acid phospholipid-containing membranes. Both activities together explain their cytotoxic
character, being rather specific when assayed against some transformed cell lines. The determination of high-resolution
structures of some ribotoxins, the characterization of a large number of mutants, and the use of lipid model vesicles and
transformed cell lines have been the tools used for the study of their mechanism of action at the molecular level. The present
knowledge suggests that wild-type ribotoxins or some modified variants might be used in human therapies. Production
of hypoallergenic mutants and immunotoxins designed against specific tumors stand out as feasible alternatives to
treat some human pathology in the mid-term future.

Tipo de documento:Artículo
Palabras clave:Asp f 1, Fungal allergy, Immunotoxin, Restrictocin, RNase, Sarcin
Materias:Ciencias Biomédicas > Farmacia > Farmacología
Ciencias Biomédicas > Farmacia > Medicamentos
Ciencias Biomédicas > Biología > Bioquímica
Ciencias Biomédicas > Biología > Biotecnología
Ciencias Biomédicas > Biología > Biología molecular
Código ID:8093
Depositado:03 Oct 2008 10:59
Última Modificación:06 Feb 2014 07:59

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