Universidad Complutense de Madrid
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Human thymic stromal lymphopoietin preferentially stimulates myeloid cells



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Reche, Pedro A y Soumelis, Vassili y Gorman, D M y Clifford, T y Liu, MR y Travis, M y Zurawski, Sandra M. y Johnston, J y Liu, Yong-Jun y Spits, H y Waal-Malefyt, Rene de y Kastelein, Robert A. y Bazan, Fernando (2001) Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. Journal of immunology (Baltimore, Md. : 1950), 167 (1). pp. 336-343. ISSN 0022-1767

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URL Oficial: http://www.jimmunol.org/content/167/1/336.abstract


The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal through a heterodimeric receptor complex that consists of a new member of the hemopoietin family termed human TSLP receptor and the IL-7R alpha-chain. Cells transfected with both receptor subunits proliferated in response to purified, recombinant human TSLP, with induced phosphorylation of Stat3 and Stat5. Human TSLPR and IL-7Ralpha are principally coexpressed on monocytes and dendritic cell populations and to a much lesser extent on various lymphoid cells. In accord, we find that human TSLP functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells, as evidenced by the strong induction of the costimulatory molecules CD40 and CD80 and the enhanced capacity to elicit proliferation of naive T cells.

Tipo de documento:Artículo
Materias:Ciencias Biomédicas > Medicina > Inmunología
Ciencias Biomédicas > Biología > Biotecnología
Ciencias Biomédicas > Biología > Biología molecular
Código ID:9345
Depositado:07 Aug 2009 12:18
Última Modificación:13 Dic 2018 12:48

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