Clustering behavior in a three-layer system mimicking olivo-cerebellar dynamics

Abstract

A model is presented that simulates the process of neuronal synchronization, formation of coherent activity clusters and their dynamic reorganization in the olivo-cerebellar system. Three coupled 2D lattices dealing with the main cellular groups in this neuronal circuit are used to model the dynamics of the excitatory feedforward loop linking the inferior olive (IO) neurons to the cerebellar nuclei (CN) via collateral axons that also proceed to terminate as climbing fiber afferents to Purkinje cells (PC). Inhibitory feedback from the CN-lattice fosters decoupling of units in a vicinity of a given IO neuron. It is shown that noise-sustained oscillations in the IO-lattice are capable to synchronize and generate coherent firing clusters in the layer accounting for the excitable collateral axons. The model also provides phase resetting of the oscillations in the IO-lattices with transient silent behavior. It is also shown that the CN-IO feedback leads to transient patterns of couplings in the IO and to a dynamic control of the size of clusters. (C) 2003 Elsevier Ltd. All rights reserved.