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Estradiol impairs the Th17 immune response against Candida albicans

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Relloso, Miguel and Aragoneses-Fenoll, Laura and Lasarte, Sandra and Bourgeois, Christelle and Romera, Gema and Kuchler, Karl and Corbí, Angel L. and Muñoz-Fernández, M. Angeles and Nombela, César and Rodríguez-Fernández, José L. and Díez-Orejas, Rosalia (2012) Estradiol impairs the Th17 immune response against Candida albicans. Journal of leukocyte biology, 91 (1). pp. 159-65. ISSN 1938-3673

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Abstract

Candida albicans is a commensal opportunistic pathogen that is also a member of gastrointestinal and reproductive tract microbiota. Exogenous factors, such as oral contraceptives, hormone replacement therapy, and estradiol, may affect susceptibility to Candida infection, although the mechanisms involved in this process have not been elucidated. We used a systemic candidiasis model to investigate how estradiol confers susceptibility to infection. We report that estradiol increases mouse susceptibility to systemic candidiasis, as in vivo and ex vivo estradiol-treated DCs were less efficient at up-regulating antigen-presenting machinery, pathogen killing, migration, IL-23 production, and triggering of the Th17 immune response. Based on these results, we propose that estradiol impairs DC function, thus explaining the increased susceptibility to infection during estrus.


Item Type:Article
Uncontrolled Keywords:Microbiología
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:21947
Deposited On:25 Jun 2015 12:32
Last Modified:01 Jul 2015 11:49

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