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The Advantage of Arriving First: Characteristic Times in Finite Size Populations of Error-Prone Replicators



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Marín Aguacil, Arturo and Tejero Franco, Héctor and Nuño Sanz, Juan Carlos and Montero Carnerero, Francisco (2013) The Advantage of Arriving First: Characteristic Times in Finite Size Populations of Error-Prone Replicators. PLOS ONE, 8 (12). ISSN 1932-6203

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Official URL: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083142


We study the evolution of a finite size population formed by mutationally isolated lineages of error-prone replicators in a two-peak fitness landscape. Computer simulations are performed to gain a stochastic description of the system dynamics. More specifically, for different population sizes, we compute the probability of each lineage being selected in terms of their mutation rates and the amplification factors of the fittest phenotypes. We interpret the results as the compromise between the characteristic time a lineage takes to reach its fittest phenotype by crossing the neutral valley and the selective value of the sequences that form the lineages. A main conclusion is drawn: for finite population sizes, the survival probability of the lineage that arrives first to the fittest phenotype rises significantly.

Item Type:Article
Uncontrolled Keywords:Quasi-species ; high mutation-rates; asexual populations; separating causes; mutators; consequences; optimization; genotype; adaptation; thresholds; computer simulation
Subjects:Medical sciences > Biology > Molecular biology
Medical sciences > Biology > Biomathematics
Medical sciences > Biology > Evolution
Medical sciences > Biology > Genetics
ID Code:29335
Deposited On:25 Mar 2015 11:33
Last Modified:25 Mar 2015 11:33

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