Magnesium substitution in brushite cements for enhanced bone tissue regeneration



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Cabrejos-Azama, Jatsué and Hamdan Alkhraisat, Mohammad and Rueda, Carmen and Torres García-Denche, Jesús and Blanco, Luis and López-Cabarcos, Enrique (2014) Magnesium substitution in brushite cements for enhanced bone tissue regeneration. Materials Science and Engineering C, 43 . pp. 403-410. ISSN 0928-4931

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We have synthesized calcium phosphate cements doped with different amounts of magnesium (Mg-CPC)with a twofold purpose: i)to evaluate in vitro the osteoblast cell response to this material and ii) to compare the bone regeneration capacity of the doped material with a calcium cement prepared without magnesium (CPC). Cell proliferation and in vivo response increased in the Mg-CPC's in comparison with CPC. The Mg-CPC's have promoted higher new bone formation than the CPC (p<0.05). The cytocompatibility and histomorfometric analysis performed in the rabbit calvaria showed that the incorporation of magnesium ions in CPC improves osteoblasts proliferation and provides higher new bone formation. The development of a bone substitute with controllable biodegradable properties and improved bone regeneration can be considered a step toward personalized therapy that can adapt to patient needs and clinical situations.

Item Type:Article
Uncontrolled Keywords:Calcium phosphate cement ; Brushite ; Magnesium ; Osteoblast ; Bone regeneration
Subjects:Medical sciences > Dentistry > Dental materials
ID Code:29951
Deposited On:06 May 2015 11:52
Last Modified:29 Nov 2018 11:23

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