Factores en la morbilidad respiratoria de los recién nacidos de muy bajo peso con membrana hialina
Factors related to respiratory complications in very low birth weight infants with respiratory distress syndrome



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García Arias, M.B. and Zuluaga Arias, Pilar and Arrabal Terán, M. C. and Arizcun Pineda, J. (2007) Factores en la morbilidad respiratoria de los recién nacidos de muy bajo peso con membrana hialina. Anales de pediatría, 66 (4). pp. 375-381. ISSN 1695-4033

Official URL: http://www.sciencedirect.com/science/article/pii/S1695403307704307


Introduction: Very low birth weight (VLBW) infants, with a birth weight below 1500 g and a structurally immature lung, are at high risk for developing bronchopulmonary dysplasia. This risk is even higher if respiratory distress syndrome is present. Other acute lung diseases, such as air leak and pulmonary hemorrhage, can also be present. The aim of this study was to analyze the statistical relevance of several neonatal factors in the development of pulmonary complications in a sample of VLBW infants with respiratory distress syndrome. Patients and methods: A total of 209 VLBW infants with respiratory distress syndrome were studied. The variables analyzed were delivery date, respiratory distress syndrome grade, sex, birth weight, gestational age, referral (from within the hospital or elsewhere), prenatal corticosteroid administration, type of gestation, type of delivery, amniorrhexis time, Apgar test at 1 and 5 minutes, surfactant administration, hours of life at which the first dose of surfactant was administered, and early sepsis. A multiple logistic regression analysis was developed using Hosmer-Lemeshow methodology. Results: In the multivariate analysis, air leak was related to respiratory distress syndrome grade and surfactant administration. Pulmonary hemorrhage was related to lower birth weight and absence of prenatal corticosteroid administration. Bronchopulmonary dysplasia was related to single pregnancies, absence of prenatal corticosteroid administration, lower birth weight, lower Apgar score at 1 minute, and higher respiratory distress syndrome grade. Conclusions: Respiratory morbidity in VLBW infants with respiratory distress syndrome could be influenced by several interrelated intrinsic and extrinsic variables

Item Type:Article
Uncontrolled Keywords:Air leak; Bronchopulmonary dysplasia; Logistic regression analysis; Pulmonary hemorrhage; Respiratory distress syndrome; Very low birth weight infants. EMTREE drug terms: corticosteroid; surfactant EMTREE medical terms: Apgar score; article; birth weight; controlled study; delivery; disease severity; gestational age; human; infant; lung dysplasia; lung hemorrhage; major clinical study; patient referral; prenatal care; respiratory distress syndrome; sepsis; very low birth weight MeSH: Anti-Inflammatory Agents; Female; Hemorrhage; Humans; Infant, Newborn; Infant, Premature; Infant, Very Low Birth Weight; Lung Diseases; Male; Respiratory Distress Syndrome, Newborn; Risk Factors; Spain
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30661
Deposited On:03 Jun 2015 08:21
Last Modified:03 Jun 2015 08:21

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