Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography



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Fernández, A. and Rodríguez-Palancas, A. and López-Ibor, M. and Zuluaga Arias, Pilar and Turrero, Agustín and Maestú Unturbe, Fernando and Amo, C. and López-Ibor, Jr., J.J. and Ortiz, T. (2005) Increased occipital delta dipole density in major depressive disorder determined by magnetoencephalography. Journal of Psychiatry and Neuroscience, 30 (1). pp. 17-23. ISSN 1180-4882

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Objective: To test the hypothesis that there is increased low-frequency activity located predominantly in the frontal lobe in patients with major depressive disorder using magnetoencephalography. Methods: We carried out an unmatched or separate sampling case-control study of 31 medication-free patients who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), criteria for major depressive disorder and were outpatients of the Hospital Central de la Defensa, Madrid, and 22 healthy control subjects with no history of mental illness. A logistic regression analysis was employed to examine the predictive value of magnetoencephalography dipole density scores in the diagnosis of depression. We attempted to locate generators of focal magnetic slow waves by employing a single moving dipole model and by calculating dipole densities in prefrontal, frontal, parietal, temporal and occipital areas. The study lasted from February 2001 to January 2003. Results: Only 2 dipole density scores, right occipital delta and left temporal delta, were significantly related to depression. According to the comparison of univariate and multivariate models and odds ratios, the right occipital delta dipole density is the factor with the greatest predictive power for depression, and the only one to show a significant correlation with severity of depression. Conclusions: We did not find any frontal lobe functional alteration. Our study provides, to the best of our knowledge, the first evidence of abnormal focal magnetic low-frequency activity in the occipital lobe of untreated patients with depression. Increased occipital lobe delta dipole density seems to be a reliable risk factor for depression, which correlates with disease severity according to the Hamilton Rating Scale for Depression.

Item Type:Article
Uncontrolled Keywords:EMTREE medical terms: adult; article; brain circulation; brain mapping; case control study; clinical article; controlled study; delta rhythm; dipole; dipole density; disease severity; female; frontal cortex; frontal lobe; human; magnetoencephalography; major depression; male; occipital cortex; occipital lobe; outpatient; parietal lobe; prediction; prefrontal cortex; risk; slow brain wave; Spain; statistical model; temporal cortex; electrooculography; epidemiology; eye movement; hemispheric dominance; instrumentation; major depression; middle aged; occipital lobe; pathophysiology; physiology; questionnaire MeSH: Adult; Delta Rhythm; Depressive Disorder, Major; Electrooculography; Eye Movements; Female; Functional Laterality; Humans; Magnetoencephalography; Male; Middle Aged; Occipital Lobe; Questionnaires; Sampling Studies
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30715
Deposited On:08 Jun 2015 08:15
Last Modified:10 Jan 2022 13:00

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