Dipole density of low-frequency and spike magnetic activity: A reliable procedure in presurgical evaluation of temporal lobe epilepsy



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Fernández, Alberto and de Sola, Rafael G. and Amo, Carlos and Turrero, Agustín and Zuluaga Arias, Pilar and Maestú Unturbe, Fernando and Campo, Pablo and Ortiz, Tomás (2004) Dipole density of low-frequency and spike magnetic activity: A reliable procedure in presurgical evaluation of temporal lobe epilepsy. Journal of Clinical Neurophysiology, 21 (4). pp. 254-266. ISSN 0736-0258

Official URL: http://journals.lww.com/clinicalneurophys/Abstract/2004/07000/Dipole_Density_of_Low_Frequency_and_Spike_Magnetic.4.aspx


Conventional visual analysis and dipole density analysis of magnetoencephalographic data for both spike and low-frequency magnetic activity were compared for presurgical evaluation in temporal lobe epilepsy (TLE) in a sample of 26 drug-resistant operated TLE patients. A series of logistic regression analyses were performed. Dipole density sensitivity was superior to visual localization analysis. Three separated logistic models were calculated for interictal spikes, low-frequency magnetic activity, and the combination of both measures. A combined interictal spike/low-frequency magnetic activity model predicted correctly the operated temporal lobe in all patients. Clear-cut criteria for the probability model are proposed that are valid for 92.3% of cases in the sample. The quantitative approach proposed by this study is an evidence-based model for presurgical evaluation of temporal lobe epilepsy, which improves previous magnetoencephalographic investigations and establishes working clinical criteria for patient evaluation in TLE.

Item Type:Article
Uncontrolled Keywords:Interictal; Low-frequency magnetic activity; Magnetoencephalography; Temporal lobe epilepsy EMTREE medical terms: adolescent; adult; article; clinical article; comparative study; controlled study; dipole; evidence based medicine; female; human; logistic regression analysis; magnetism; magnetoencephalography; male; preoperative evaluation; spike; statistical model; temporal lobe epilepsy; visual orientation MeSH: Adolescent; Adult; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Logistic Models; Magnetoencephalography; Male; Middle Aged; Models, Statistical; Preoperative Care
Subjects:Sciences > Mathematics > Applied statistics
Medical sciences > Biology
ID Code:30718
Deposited On:08 Jun 2015 08:33
Last Modified:10 Jan 2022 12:57

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