Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects



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Liras, Antonio (2010) Future research and therapeutic applications of human stem cells: general, regulatory, and bioethical aspects. Journal of translational medicine, 8 . pp. 1-15. ISSN 1479-5876

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Official URL: http://www.translational-medicine.com/content/8/1/131


There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells, both embryonic as adult stem cells, for several therapeutic indications (cardiovascular and ischemic diseases,diabetes, hematopoietic diseases, liver diseases). Along with recent progress in transference of nuclei from human somatic cells, as well as iPSC technology, has allowed availability of lineages
of all three germ layers genetically identical to those of the donor patient, which permits safe transplantation of organ-tissue-specific adult stem cells with no immune rejection. The main objective is the need for expansion of stem cell characteristics to maximize stem cell efficacy (i.e. the proper selection of a stem cell) and the efficacy (maximum effect) and safety of stem cell derived drugs. Other considerations to take into account in cell therapy will be the suitability of infrastructure and technical staff, biomaterials, production costs, biobanks, biosecurity, and the biotechnological industry. The general objectives in the area of stem cell research in the next few years, are related to identification of therapeutic targets and potential therapeutic tests, studies of cell differentiation and physiological
mechanisms, culture conditions of pluripotent stem cells and efficacy and safety tests for stem cellbased drugs or procedures to be performed in both animal and human models in the corresponding clinical trials. A regulatory framework will be required to ensure patient accessibility to products and governmental assistance for
their regulation and control. Bioethical aspects will be required related to the scientific and therapeutic relevance and cost of cryopreservation over time, but specially with respect to embryos which may ultimately be used for scientific uses of research as source of embryonic stem cells, in which case the bioethical conflict may be further aggravated.

Item Type:Article
Uncontrolled Keywords:Stem cells, Hemophlia, Avanced therapies
Subjects:Medical sciences > Medicine > Hematology
Medical sciences > Biology > Biotechnology
ID Code:30757
Deposited On:12 Jun 2015 11:08
Last Modified:12 Jun 2015 11:08

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