Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease



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García Martín, Elena Salobrar and Hoz Montañana, María Rosa de and Rojas López, María Blanca and Ramírez Sebastián, Ana Isabel and Salazar Corral, Juan José and Yubero Pancorbo, Raquel and Gil Gregorio, Pedro and Triviño Casado, Alberto and Ramirez Sebastian, Jose Manuel (2015) Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease. Journal of Ophthalmology, 2015 . pp. 1-10. ISSN 2090-004X

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Official URL: http://dx.doi.org/10.1155/2015/736949


Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD patients and 28 age-matched control subjects with mean Mini Mental State Examination of 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision were included. Best-corrected visual acuity (VA), contrast sensitivity (CS) (3, 6, 12, and 18 cpds), color perception (CP), and perception digital test (PDT) were tested in one eye of each patient. Results. In comparison with the controls, MAD patients presented (i) a significant decrease in VA, PDT, and CS for all spatial frequencies analyzed, especially the higher ones, and (ii) a significant increase in unspecific errors on the blue axis (P < 0.05 in all instances). In MAD patients, a wide a ROC curve was plotted in all PTs. Conclusions. In MAD, CS, VA, and the tritan axis in CP were impaired. The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. PT abnormalities are consistent with the structural findings reported in the same MAD patients using OCT.

Item Type:Article
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Copyright © 2015 Elena Salobrar-Garcia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Uncontrolled Keywords:OCT; Optical Coherence Tomography; Nerve-Fiber Layer; Contrast Sensivity; COognitive Impairment; Visual Dysfunction; Retinal Pathology; Senile Dementia; Alzheimer;
Subjects:Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine
Medical sciences > Medicine > Geriatrics
Medical sciences > Medicine > Neurosciences
Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Eyes anatomy
Medical sciences > Optics > Imaging systems
ID Code:31233
Deposited On:03 Jul 2015 09:50
Last Modified:07 Jul 2015 11:28

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