A unified nomenclature and amino acid numbering for human PTEN.



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Pulido, Rafael and Baker, Suzanne J. and Barata, Joao T. and Carracedo, Arkaitz and Cid, Víctor J. and Chin-Sang, Ian D. and Davé, Vrushank and Hertog, Jeroen den and Devreotes, Peter and Eickholt, Britta J. and Eng, Charis and Furnari, Frank B. and Georgescu, María Magdalena and Gericke, Arne and Hopkins, Benjamin and Jiang, Xeujun and Lee, Seung Rock and Lösche, Mathias and Malaney, Prerna and Matias Guiu, Xavier and Molina, María and Pandolfi, Pier Paolo and Parsons, Ramon and Pinton, Paolo and Rivas, Carmen and Rocha, Rafael M. and Rodríguez, Manuel S. and Ross, Alonzo H. and Serrano, Manuel and Stambolic, Vuk and Stiles, Bangyan and Suzuki, Akira and Tan, Seong Seng and Tonks, Nicholas K. and Trotman, Lloyd C. and Wolff, Nicolas and Woscholski, Rudiger and Wu, Hong and Leslie, Nicholas R. (2014) A unified nomenclature and amino acid numbering for human PTEN. Science signaling, 7 (332). pe15. ISSN 1945-0877

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Official URL: http://dx.doi.org/10.1126/scisignal.2005560


The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.

Item Type:Article
Uncontrolled Keywords:PTEN, unified nomenclature, amino acid numbering
Subjects:Medical sciences > Pharmacy > Microbiology
ID Code:33631
Deposited On:26 Nov 2015 11:54
Last Modified:26 Nov 2015 11:54

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