Publication: Cambios bioquímicos del metabolismo óseo durante el movimiento ortodóncico
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2016-04-19
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Martín Alvaro, Concepción
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Universidad Complutense de Madrid
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Abstract
Desde la primera biopsia de un diente al que se le aplicó una fuerza allá por el año 1901 (Meikle, 2006; Wöstmann et al., 2008), la comunidad científica, en concreto la odontológica, siempre se preguntó cómo podía moverse un diente a través del hueso alveolar. Hoy, más de 100 años después, seguimos sin saber con exactitud todos los factores que influyen en este proceso pero hacemos un esfuerzo por conocerlo cada vez más a fondo. El entendimiento de los factores más influyentes en este remodelado óseo podría acarrear múltiples ventajas. Entre ellas destacaríamos un mayor control del movimiento ortodóncico, modificaciones en la velocidad del mismo, disminución del dolor, ejecución de movimientos fuera del alcance de la ortodoncia actual e incluso poder comprender y diferenciar las distintas técnicas ortodóncicas desde un punto de vista molecular. Partiendo del conocimiento de la biología ósea y en base a estudios previos en el campo de la ortodoncia y biología molecular, la utilización de diferentes métodos de inmunodiagnóstico (searchlight, westren blot y citometría de flujo con Luminex) nos permitirán detectar la presencia de varios mediadores bioquímicos mediante la toma de muestras de fluido crevicular con puntas de papel...
Since the first biopsy of a tooth to which a force was applied back in 1901 (Meikle, 2006; Wöstmann et al, 2008), scientific community, specifically the dental one, always wondered how a tooth could move through alveolar bone. Today, over one hundred years later, we still do not know exactly all the factors that influence this process but we make an effort to gain a deeper and comprehensive knowledge. The understanding of the most influential factors in this bone remodelling could give rise to many advantages. Among these, we would highlight a greater control of orthodontic movement, changes in its speed, decreased pain, execution of movements away from current orthodontics and even being able to understand and distinguish the different orthodontic treatments from a molecular standpoint. Based on the knowledge about bone biology and on previous studies in the field of orthodontics and molecular biology, using different immunodiagnostic methods (searchlight, western blot and Luminex flow cytometry) would allow us to detect the presence of various biochemical mediators by sampling
Since the first biopsy of a tooth to which a force was applied back in 1901 (Meikle, 2006; Wöstmann et al, 2008), scientific community, specifically the dental one, always wondered how a tooth could move through alveolar bone. Today, over one hundred years later, we still do not know exactly all the factors that influence this process but we make an effort to gain a deeper and comprehensive knowledge. The understanding of the most influential factors in this bone remodelling could give rise to many advantages. Among these, we would highlight a greater control of orthodontic movement, changes in its speed, decreased pain, execution of movements away from current orthodontics and even being able to understand and distinguish the different orthodontic treatments from a molecular standpoint. Based on the knowledge about bone biology and on previous studies in the field of orthodontics and molecular biology, using different immunodiagnostic methods (searchlight, western blot and Luminex flow cytometry) would allow us to detect the presence of various biochemical mediators by sampling
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Tesis inédita de la Universidad Complutense de Madrid de la Facultad de Odontología del Departamento de Estomatología III, leída el 26-11-2015