Publication: Un canal de potasio activado por calcio regula la secreción muscarínica en célula cromafín felina
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2002
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Universidad Complutense de Madrid, Servicio de Publicaciones
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Abstract
En esta tesis doctoral se ha realizado un detallado estudio del proceso secretor mediado por la estimulación del receptor muscarínico de la médula adrenal de gato y las implicaciones de los canales de R(+) activados por Ca(+2) tienen en este y tras el análisis de la cinética de la estimulación prolongada de este receptor y de las distintas fuentes de calcio que participan en la respuesta secretora. Hemos concluido, que los canales de potasio dependientes de Ca(+2) modulan la respuesta muscarínica contrarestando la despolarización que la estimulación de este receptor genera autolimitando el disparo de potenciales de acción y la respuesta secretora que se potencia al bloquear tales canales. Estos canales parecen corresponder al tipo SR por la disección farmacológica realizada. Por otro lado hemos podido establecer un patrón tanto para la secrección como ..
In this doctoral thesis, a detailed study of the secretory process mediated by the stimulation of the cat adrenal medulla muscarinic receptor and the implications of the R (+) channels activated by Ca (+2) have in this and after the analysis of the kinetics of prolonged stimulation of this receptor and of the different sources of calcium that participate in the secretory response. We have concluded that Ca (+2) -dependent potassium channels modulate the muscarinic response, counteracting the depolarization that stimulation of this receptor generates, self-limiting the triggering of action potentials and the secretory response that is enhanced by blocking such channels. These channels appear to correspond to the SR type due to the pharmacological dissection performed. On the other hand we have been able to establish a pattern for both secretion and ..
In this doctoral thesis, a detailed study of the secretory process mediated by the stimulation of the cat adrenal medulla muscarinic receptor and the implications of the R (+) channels activated by Ca (+2) have in this and after the analysis of the kinetics of prolonged stimulation of this receptor and of the different sources of calcium that participate in the secretory response. We have concluded that Ca (+2) -dependent potassium channels modulate the muscarinic response, counteracting the depolarization that stimulation of this receptor generates, self-limiting the triggering of action potentials and the secretory response that is enhanced by blocking such channels. These channels appear to correspond to the SR type due to the pharmacological dissection performed. On the other hand we have been able to establish a pattern for both secretion and ..
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacología, leída el 14-09-1993