Pupillary behavior in relation to wavelength and age



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Lobato Rincón, Luis-Lucio and Cabanillas Campos, María del Carmen and Bonnin Arias, Cristina and Chamorro Gutiérrez, Eva and Sanchez Ramos, Celia and Murciano Cespedosa, Antonio (2014) Pupillary behavior in relation to wavelength and age. Frontiers in Human Neuroscience, 8 (1). ISSN 1662-5161

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Official URL: http://dx.doi.org/10.3389/fnhum.2014.00221


Pupil light reflex can be used as a non-invasive ocular predictor of cephalic autonomic nervous system integrity. Spectral sensitivity of the pupil's response to light has, for some time, been an interesting issue. It has generally, however, only been investigated with the use of white light and studies with monochromatic wavelengths are scarce. This study investigates the effects of wavelength and age within three parameters of the pupil light reflex (amplitude of response, latency, and velocity of constriction) in a large sample of younger and older adults (N = 97), in mesopic conditions. Subjects were exposed to a single light stimulus at four different wavelengths: white (5600° K), blue (450 nm), green (510 nm), and red (600 nm). Data was analyzed appropriately, and, when applicable, using the General Linear Model (GLM), Randomized Complete Block Design (RCBD), Student's t-test and/or ANCOVA. Across all subjects, pupillary response to light had the greatest amplitude and shortest latency in white and green light conditions. In regards to age, older subjects (46-78 years) showed an increased latency in white light and decreased velocity of constriction in green light compared to younger subjects (18-45 years old). This study provides data patterns on parameters of wavelength-dependent pupil reflexes to light in adults and it contributes to the large body of pupillometric research. It is hoped that this study will add to the overall evaluation of cephalic autonomic nervous system integrity.

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Open Access en la web del editor.
Received: 26 August 2013; Accepted: 28 March 2014;Published online: 22 April 2014.
This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.
Copyright © 2014 Lobato-Rincón, Cabanillas-Campos, Bonnin-Arias, Chamorro-Gutiérrez, Murciano-Cespedosa and Sánchez-Ramos Roda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Uncontrolled Keywords:Aging; Mesopic conditions; Ocular predictor; Pupil light reflex; Pupillometry; Wavelength; Autonomic nervous system
Subjects:Medical sciences > Medicine > Physiology
Medical sciences > Medicine > Neurosciences
Medical sciences > Optics > Optometry
Medical sciences > Optics > Visual perception
Medical sciences > Optics > Eyes anatomy
ID Code:38656
Deposited On:29 Aug 2016 12:33
Last Modified:01 Sep 2016 10:04

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