Diadenosine polyphosphates after laser in situ keratomileusis and photorefractive keratectomy refractive techniques



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Carracedo Rodríguez, Juan Gonzalo and Cacho, Isabel and Sánchez Naves, Juan and Pintor, Jesús (2014) Diadenosine polyphosphates after laser in situ keratomileusis and photorefractive keratectomy refractive techniques. Acta Ophthalmologica, 92 (1). e5-e11. ISSN 1755-375X

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Official URL: http://dx.doi.org/10.1111/aos.12194


Purpose:  To study the concentrations of diadenosine polyphosphates in the ocular surface after PRK and LASIK.
Methods:  Sixty-one patients (30 males and 31 females) with ages ranging from 20 to 63 (34.04 ± 9.13 years) were recruited in Balear Institute of Ophthalmology, Palma de Mallorca, Spain. LASIK was performed in 92 eyes of 46 patients and PRK in 25 eyes of 15 patients. Variations in the levels of diadenosine polyphosphate (Ap4A and Ap5A), Schirmer I (Jones test), TBUT, corneal staining together with the Dry Eye Questionnaire to evaluate discomfort and dryness were studied. All tests were performed at the preoperative visit and at 1-day, 2-week, 1-month and 3-month postoperative visits.
Results:  Ap4A showed a 5 and 3.5 fold increase at the 1-day visit for LASIK and PRK, respectively. LASIK patients continued having higher statistically significant concentrations (p = 0.01) all over the follow-up. Ap5A showed no significant differences at any visit. Tear volume decreased during the 3 months in LASIK. The PRK cases had a normal volume at 1 month. TBUT in LASIK increased at the 1-day visit (p = 0,002) and decreased from the 2 weeks onwards and for the PRK, decreased by a 35% at the 1-day visit and kept reduced for a month. Discomfort only increased at the 1-day visit (p = 0.007). Dryness frequency was similar in all visits.
Conclusions:  Ap4A levels only are increased in refractive surgery patients during the first day after the surgery. This increasing suggests that Ap4A may help accelerating the healing process.

Item Type:Article
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Recibido: 14 de febrero; aceptado 30 dee abril de 2013; Disponible online: 22 de enero de 2014

Uncontrolled Keywords:dinucleotides; dry eye; LASIK; PRK; wound healing; keratectomy
Subjects:Sciences > Chemistry > Biochemistry
Medical sciences > Medicine > Surgery
Medical sciences > Medicine > Ophtalmology
ID Code:39154
Deposited On:27 Sep 2016 10:17
Last Modified:29 Sep 2016 07:38

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