Publication: Determinación de la actividad de superóxido dismutasa en poblaciones humanas normales y patológicas
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2002
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Universidad Complutense de Madrid, Servicio de Publicaciones
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Abstract
El tema de esta tesis doctoral, que se enmarca dentro del contexto de la actuación de sustancias detoxificantes de radicales libres en el organismo, aporta nuevos datos respecto a la actividad del enzima superóxido dismutasa (sod), en la población española sana desde el nacimiento hasta los 93 años. Esto ha permitido no solo establecer un patrón de referencia de la población hispana, sino también de determinar la variación del enzima según el estado de desarrollo del individuo, realizando nuevas aportaciones a la teoría de los radicales libres y el envejecimiento humano. Por otra parte, se analizan las interacciones de este enzima en diferentes medios rurales y urbanos, observándose una mayor actividad de sod en el medio urbano. Finalmente, se ha analizado el comportamiento de la sod en diversas patologías, algunas de ellas consideradas como propias del paso de los años (cataratas, osteoporosis, problemas osteoarticulares, hipertensión, etc.), y otras con alta incidencia en la población, como cáncer y diabetes y en pacientes con Síndrome de Down, por estar localizado el gen de la sod en el cromosoma 21
The topic of this doctoral thesis, which is framed within the context of the action of free radical detoxifying substances in the body, provides new data regarding the activity of the enzyme superoxide dismutase (sod), in the healthy Spanish population from birth to the 93 years. This has allowed not only to establish a reference pattern for the Hispanic population, but also to determine the variation of the enzyme according to the state of development of the individual, making new contributions to the theory of free radicals and human aging. On the other hand, the interactions of this enzyme in different rural and urban environments are analyzed, observing a greater activity of sod in the urban environment. Finally, the behavior of sod has been analyzed in various pathologies, some of them considered as characteristic of the passing of the years (cataracts, osteoporosis, osteoarticular problems, hypertension, etc.), and others with high incidence in the population, such as cancer. and diabetes and in Down syndrome patients, because the sod gene is located on chromosome 21
The topic of this doctoral thesis, which is framed within the context of the action of free radical detoxifying substances in the body, provides new data regarding the activity of the enzyme superoxide dismutase (sod), in the healthy Spanish population from birth to the 93 years. This has allowed not only to establish a reference pattern for the Hispanic population, but also to determine the variation of the enzyme according to the state of development of the individual, making new contributions to the theory of free radicals and human aging. On the other hand, the interactions of this enzyme in different rural and urban environments are analyzed, observing a greater activity of sod in the urban environment. Finally, the behavior of sod has been analyzed in various pathologies, some of them considered as characteristic of the passing of the years (cataracts, osteoporosis, osteoarticular problems, hypertension, etc.), and others with high incidence in the population, such as cancer. and diabetes and in Down syndrome patients, because the sod gene is located on chromosome 21
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Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Bioquímica y Biología Molecular II, leída el 18-01-1995