Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela



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Delgado Blas, José Francisco and Martínez Ovejero, Cristina and Abadia Patiño, Lorena and González Zorn, Bruno (2016) Coexistence of mcr-1 and blaNDM-1 in Escherichia coli from Venezuela. Antimicrobial agents and chemotherapy, 60 (10). pp. 6356-8. ISSN 0066-4804

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We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolates from swine (novel ST452) and human (ST19) samples that were resistant to colistin. Whole-genome sequencing and transformation experiments identified mcr-1 on an IncI2 plasmid. One of the isolates also bore the widely spread carbapenemase NDM-1. A One Health approach is necessary to further elucidate the flux of these high-risk genes.

Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39608
Deposited On:09 Jan 2017 16:22
Last Modified:09 Jan 2017 16:22

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