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Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota



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Drumo, Rosanna and Pesciaroli, Michele and Ruggeri, Jessica and Tarantino, Michela and Chirullo, Barbara and Pistoia, Claudia and Petrucci, Paola and Martinelli, Nicola and Moscati, Livia and Manuali, Elisabetta and Pavone, Silvia and Picciolini, Matteo and Ammendola, Serena and Gabai, Gianfranco and Battistoni, Andrea and Pezzotti, Giovanni and Alborali, Giovanni L and Napolioni, Valerio and Pasquali, Paolo and Magistrali, Chiara F (2015) Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota. Frontiers in cellular and infection microbiology, 5 . p. 106. ISSN 2235-2988

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Official URL: https://doi.org/10.3389/fcimb.2015.00106


Salmonella enterica serovar Typhimurium is an important zoonotic gastrointestinal pathogen responsible for foodborne disease worldwide. It is a successful enteric pathogen because it has developed virulence strategies allowing it to survive in a highly inflamed intestinal environment exploiting inflammation to overcome colonization resistance provided by intestinal microbiota. In this study, we used piglets featuring an intact microbiota, which naturally develop gastroenteritis, as model for salmonellosis. We compared the effects on the intestinal microbiota induced by a wild type and an attenuated S. Typhimurium in order to evaluate whether the modifications are correlated with the virulence of the strain. This study showed that Salmonella alters microbiota in a virulence-dependent manner. We found that the wild type S. Typhimurium induced inflammation and a reduction of specific protecting microbiota species (SCFA-producing bacteria) normally involved in providing a barrier against pathogens. Both these effects could contribute to impair colonization resistance, increasing the host susceptibility to wild type S. Typhimurium colonization. In contrast, the attenuated S. Typhimurium, which is characterized by a reduced ability to colonize the intestine, and by a very mild inflammatory response, was unable to successfully sustain competition with the microbiota.

Item Type:Article
Uncontrolled Keywords:Salmonella Typhimurium, microbiota, inflammation, immune response, pig, salmonellosis
Subjects:Medical sciences > Veterinary
ID Code:39610
Deposited On:20 Dec 2016 09:16
Last Modified:20 Dec 2016 09:16

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