African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa



Downloads per month over past year

Berg, Stefan and García Pelayo, M Carmen and Müller, Borna and Hailu, Elena and Asiimwe, Benon and Kremer, Kristin and Dale, James and Boniotti, M Beatrice and Rodriguez, Sabrina and Hilty, Markus and Rigouts, Leen and Firdessa, Rebuma and Machado, Adelina and Mucavele, Custodia and Ngandolo, Bongo Nare Richard and Bruchfeld, Judith and Boschiroli, Laura and Müller, Annélle and Sahraoui, Naima and Pacciarini, Maria and Cadmus, Simeon and Joloba, Moses and van Soolingen, Dick and Michel, Anita L and Djønne, Berit and Aranaz Martín, Alicia and Zinsstag, Jakob and van Helden, Paul and Portaels, Françoise and Kazwala, Rudovick and Källenius, Gunilla and Hewinson, R Glyn and Aseffa, Abraham and Gordon, Stephen V and Smith, Noel H (2011) African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa. Journal of bacteriology, 193 (3). pp. 670-8. ISSN 1098-5530

[thumbnail of 404.pdf] PDF
Restringido a Repository staff only


Official URL:


We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies.

Item Type:Article
Subjects:Medical sciences > Veterinary
ID Code:39685
Deposited On:11 Jan 2017 08:36
Last Modified:11 Jan 2017 08:36

Origin of downloads

Repository Staff Only: item control page