Genetic and virulence-phenotype characterization of serotypes 2 and 9 of Streptococcus suis swine isolates



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Blume, Verena and Luque, Inmaculada and Vela Alonso, Ana I and Borge, Carmen and Maldonado, Alfonso and Domínguez Rodríquez, Lucas and Tarradas, Carmen and Fernández-Garayzábal, José Francisco (2009) Genetic and virulence-phenotype characterization of serotypes 2 and 9 of Streptococcus suis swine isolates. International microbiology: the official journal of the Spanish Society for Microbiology, 12 (3). pp. 161-6. ISSN 1618-1905

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The aim of this study was to analyze the genetic characteristics and virulence phenotypes of Streptococcus suis, specifically, in clinical isolates of serotypes 2 and 9 (n = 195), obtained from diverse geographical areas across Spain. Pulsed-field gel electrophoresis (PFGE) typing identified 97 genetic profiles, 68% of which were represented by single isolates, indicative of a substantial genetic diversity among the S. suis isolates analyzed. Five PFGE profiles accounted for 33.3% of the isolates and were isolated from 38% of the herds in nine different provinces, indicative of the bacterium's widespread distribution in the Spanish swine population. Representative isolates of the most prevalent PFGE profiles of both serotypes were subjected to multilocus sequence typing (MLST) analysis. The results indicated that serotypes 2 and 9 have distinct genetic backgrounds. Serotype 2 isolates belong to the ST1 complex, a highly successful clone that has spread over most European countries. In accordance with isolates of this complex, most serotype 2 isolates also expressed the phenotype MRP(+)EF(+)SLY(+). Serotype 9 isolates belong to the ST61 complex, which is distantly related to the widespread European ST87 clone. Also, in contrast to most isolates of the European ST87 clone, which express the large variant MRP*, the majority of serotype 9 isolates (97.9%) did not express the protein.

Item Type:Article
Uncontrolled Keywords:Streptoccoccus suis, swine, genetic typing, PFGE, MLST, virulence-related factors
Subjects:Medical sciences > Veterinary
ID Code:39694
Deposited On:22 Dec 2016 10:00
Last Modified:07 Apr 2021 07:26

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