Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration



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Puell Marín, María Cinta and Barrio de Santos, Ana Rosa and Palomo Álvarez, Catalina and Gomez-Sanz, Fernando J and Clement-Corral, Amaya and Perez Carrasco, Maria Jesus (2012) Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration. Investigative Ophthalmology and Visual Science, 53 (11). pp. 7310-7314. ISSN 0146-0404

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Purpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD).

Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions.

Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70.

Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD.

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Uncontrolled Keywords:Mediated multifocal electroretinogram; Geographic Atrphy; Dark-Adaptation; Maculopathy; Vision; Contrast; Luminance; Chart; Classification; Dysfunction
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Optometry
ID Code:39858
Deposited On:02 Nov 2016 11:20
Last Modified:03 Mar 2017 09:18

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