pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery



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Gisbert Garzarán, Miguel and Manzano García, Miguel and Vallet Regí, María (2017) pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery. Bioengineering, 4 (1). ISSN 2306-5354

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The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.

Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID K-3719-2014 (Miguel Manzano García)
RESEARCHER ID M-3378-2014 (Miguel Manzano García)
ORCID 0000-0001-6238-6111 (Miguel Manzano García)
RESEARCHER ID S-2443-2016 (Miguel Gisbert Garzarán)
ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)

Uncontrolled Keywords:Mesoporous nanoparticles; PH-responsive; Cancer; Stimuli-responsive
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:40880
Deposited On:30 Jan 2017 10:42
Last Modified:03 Feb 2017 12:21

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