Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity



Downloads per month over past year

Matesanz Sancho, María Concepción and Linares, Javier and Lilue, Isabel and Sánchez Salcedo, Sandra and Feito Castellano, María José and Arcos Navarrete, Daniel and Vallet Regí, María and Portolés Pérez, María Teresa (2014) Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity. Journal of Materials Chemistry B, 2 (19). pp. 2910-2919. ISSN 2050-750X

[thumbnail of (617) J. Mater. Chem. 2, 2910-2919   2014 DANI.pdf]


In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. Nano-SiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration.

Item Type:Article
Additional Information:

RESEARCHER ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID N-4501-2014 (Sandra Sánchez Salcedo)
ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo)

Uncontrolled Keywords:Osteoblast-like cells, Bone-resorption, In-vitro, Molecular-mechanisms, Osteoporosis, Macrophages, Vivo, Biomaterials, Bioceramics, Inhibitors
Subjects:Sciences > Chemistry
Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:40899
Deposited On:03 Feb 2017 12:04
Last Modified:05 Nov 2020 11:30

Origin of downloads

Repository Staff Only: item control page