Immunolocalisation of P2Y receptors in the rat eye



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Pintor, Jesús and Sánchez Nogueiro, Jesús and Irazu, Marta and Mediero Muñoz, Aránzazu and Pelaez, Teresa and Peral Cerdá, Assumpta (2004) Immunolocalisation of P2Y receptors in the rat eye. Purinergic Signalling, 1 (1). pp. 831-90. ISSN 1573-9538

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Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal wound healing, aqueous humour dynamics and retinal physiology. Commercial antibodies have allowed us to investigate the distribution of P2Y receptors in the cornea, anterior and posterior chamber of the eye and retina. The P2Y1 receptor was present mainly in cornea, ciliary processes, and trabecular meshwork. The P2Y2 receptors were present in cornea, ciliary processes and retinal pigmented epithelium. P2Y4 was present in cornea, ciliary processes, photoreceptors, outer plexiform layer and ganglion cell layer. The P2Y6 presented almost an identical distribution as the P2Y4 receptor. The P2Y11 was also detectable in the retinal pigmented epithelium. The detailed distribution of the receptors clearly supports the recent findings indicating the relevant role of nucleotides in the ocular function.

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En Open Access en la web del editor.
Versión en abierto en PMC.
Received: 27 September 2004 ; Revised: 18 October 2004 ; Accepted: 18 October 2004

Uncontrolled Keywords:Ciliary processes ; Cornea ; Eye ; Ocular surface ; P2 purinergic receptors ; Retina
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Biology > Animal physiology
Medical sciences > Optics > Eyes anatomy
ID Code:41036
Deposited On:07 Feb 2017 08:17
Last Modified:07 Feb 2017 08:17

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