Publication: Quimerismo leucocitario en el trasplante hepático. Hacia la utopía de la inmunotolerancia y la no inmunosupresión
Loading...
Files
Official URL
Full text at PDC
Publication Date
2017-02-08
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad Complutense de Madrid
Citations
Exportar
Abstract
El término quimérico se emplea en medicina para designar a un organismo que contiene poblaciones celulares que proceden de individuos genéticamente distintos de la misma o distinta especie. En el campo del trasplante de médula ósea el quimerismo es de especial importancia, de forma que cuando un trasplante de médula ósea tiene éxito se produce una quimera hematopoyética completa en la que todas las células linfohematopoyéticas presentes en el receptor proceden del donante, aunque a veces se puede encontrar una quimera mixta en la que una pequeña parte de las células son del receptor. Es muy importante el estudio del quimerismo, porque una pérdida de quimera del donante se asocia con una recaída de la enfermedad hematológica (ej. leucemia). En el campo del trasplante de órganos sólidos, y del trasplante hepático, se da una situación inversa en la que una pequeña parte de los leucocitos circulantes en el receptor proceden del donante. Existe la teoría de que la existencia de quimerismo leucocitario del donante en el receptor de un trasplante hepático se asocia con la tolerancia inmunológica al injerto a largo plazo...
The chimerical term is used in medicine to describe an organism that contains cell populations that comes from individuals genetically different from the same or different species. In the field of bone marrow transplantation Chimerism is of special importance, in such a way that a bone marrow transplant succeeds when we achieved a full hematopoietic chimera in which all hematopoietic cells present in the recipient come from the donor, although sometimes you can find a mixed chimera in which a small part of the cell belongs to the recipient. The study of Chimerism, is very important because a loss of chimera of the donor is associated with a relapse of hematologic disease (eg. leukemia). In the field of solid organ transplantations, and liver transplantation, it is given a “mirror image” situation in which a small part of the circulating leukocytes in the recipient comes from the donor. There is a theory that the existence of Leukocyte donor Chimerism in the recipient of a liver transplant, that is associated with immunological tolerance to graft in the long run. The discovery of powerful immunosuppressive drugs that have made it possible to greatly decrease the phenomena of rejection and grafts getting some survivals prolonged after the transplant has been very important in the development of liver transplantation...
The chimerical term is used in medicine to describe an organism that contains cell populations that comes from individuals genetically different from the same or different species. In the field of bone marrow transplantation Chimerism is of special importance, in such a way that a bone marrow transplant succeeds when we achieved a full hematopoietic chimera in which all hematopoietic cells present in the recipient come from the donor, although sometimes you can find a mixed chimera in which a small part of the cell belongs to the recipient. The study of Chimerism, is very important because a loss of chimera of the donor is associated with a relapse of hematologic disease (eg. leukemia). In the field of solid organ transplantations, and liver transplantation, it is given a “mirror image” situation in which a small part of the circulating leukocytes in the recipient comes from the donor. There is a theory that the existence of Leukocyte donor Chimerism in the recipient of a liver transplant, that is associated with immunological tolerance to graft in the long run. The discovery of powerful immunosuppressive drugs that have made it possible to greatly decrease the phenomena of rejection and grafts getting some survivals prolonged after the transplant has been very important in the development of liver transplantation...
Description
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 12-01-2016