Publication: El carcinoma broncogénico en la provincia de Segovia. Análisis de una década
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2017-02-09
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Universidad Complutense de Madrid
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Abstract
1. Introducción. El cáncer de pulmón o carcinoma broncogénico (CB) es un conjunto de enfermedades resultantes del crecimiento descontrolado de células del tracto respiratorio. El lugar de origen puede ser el bronquio, el propio parénquima o la pleura. Independientemente de donde se origina se entiende que es una misma enfermedad. El agente etiológico más frecuente y claramente demostrado es el tabaco, aunque existen otros factores que también se ha demostrado como causa de CB. Existen 4 tipos fundamentales de CB, Epidermoide, Adenocarcinoma, Carcinoma de Células Grandes y Microcítico. Existe un aumento de casos de Adenocarcinoma, aunque en nuestro país el más frecuente sigue siendo el Epidermoide. La mayoría de los pacientes son varones pero en los últimos años ha aumentado el número de mujeres, fiel reflejo de la incorporación al tabaquismo a lo largo del tiempo. La edad al diagnóstico es avanzada, sobre todo en varones y se acompaña de comorbilidad. El tratamiento empleado más frecuentemente es la QT. La supervivencia global es baja y está muy influenciada por el tratamiento quirúrgico y el grado de extensión del CB. 2. Objetivos: El objetivo principal es conocer las características epidemiológicas de todos los pacientes diagnosticados de CB en la provincia de Segovia desde el año 2000 al 2010. Otros objetivos son: 1. Analizar la incidencia a lo largo del tiempo 2. Estudiar el diagnóstico por sexo durante el periodo de estudio 3. Evaluar los cambios en la histología del CB 4. Analizar la supervivencia global a 5 años en la población a estudio 5. Estudiar la supervivencia en función de la extensión, sexo, edad y tratamiento recibido 6. Evaluar la comorbilidad y su impacto en la supervivencia...
1. Introduction. Carcinoma or lung cancer bronchogenic (CB) is a set of diseases resulting from the uncontrolled growth of cells of the respiratory tract. The place of origin can be the bronchus, own parenchyma or the pleura. Regardless of where originates means that it is a disease. The Etiologic Agent more frequently and clearly demonstrated is tobacco, although there are other factors that also has been proven as a cause of CB. There are 4 basic types of CB, squamous cell, Adenocarcinoma, large cell and non-small Cell Carcinoma. There is an increase in cases of Adenocarcinoma, although in our country the most frequent is still the squamous cell. The majority of patients are male but in recent years has increased the number of women, faithful reflection of the addition to the smoking over time. Age at diagnosis is an advanced, especially in males, and is accompanied by comorbidity. The treatment most frequently used is the QT. Overall survival is low and is very influenced by the surgical treatment and the degree of extension of the CB. 2 Objectives. The main objective is determining the epidemiological characteristics of all patients diagnosed with CB in the province of Segovia from 2000 to 2010. Other objectives are: 1. Analyze the incidence over time 2. Study the diagnosis by sex during the study period 3. Assess changes in histology of the CB 4. Analyze the overall survival at 5 years in the study population 5. Study the survival depending on the extension, sex, age and treatment received 6. Assess the co-morbidity and its impact on survival...
1. Introduction. Carcinoma or lung cancer bronchogenic (CB) is a set of diseases resulting from the uncontrolled growth of cells of the respiratory tract. The place of origin can be the bronchus, own parenchyma or the pleura. Regardless of where originates means that it is a disease. The Etiologic Agent more frequently and clearly demonstrated is tobacco, although there are other factors that also has been proven as a cause of CB. There are 4 basic types of CB, squamous cell, Adenocarcinoma, large cell and non-small Cell Carcinoma. There is an increase in cases of Adenocarcinoma, although in our country the most frequent is still the squamous cell. The majority of patients are male but in recent years has increased the number of women, faithful reflection of the addition to the smoking over time. Age at diagnosis is an advanced, especially in males, and is accompanied by comorbidity. The treatment most frequently used is the QT. Overall survival is low and is very influenced by the surgical treatment and the degree of extension of the CB. 2 Objectives. The main objective is determining the epidemiological characteristics of all patients diagnosed with CB in the province of Segovia from 2000 to 2010. Other objectives are: 1. Analyze the incidence over time 2. Study the diagnosis by sex during the study period 3. Assess changes in histology of the CB 4. Analyze the overall survival at 5 years in the study population 5. Study the survival depending on the extension, sex, age and treatment received 6. Assess the co-morbidity and its impact on survival...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 26/01/2016