Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma



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Saenz Frances, Federico and Jañez Escalada, Luis and Borrego Sanz, Lara and Berrozpe Villabona, Clara and Martínez de la Casa, Jose Maria and Morales Fernández, Laura and García Sánchez, Julián and Santos Bueso, Enrique and García Feijoo, Julián (2015) Correlations between corneal and optic nerve head variables in healthy subjects and patients with primary open angle glaucoma. International journal of ophthalmology, 8 (6). pp. 1156-1161. ISSN 2222-3959

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AIM: To correlate corneal variables (determined using the Pentacam) with optic nerve head (ONH) variables determined using the Heidelberg retina tomograph (HRT) in healthy subjects and patients diagnosed with primary open angle glaucoma (POAG).
METHODS: Measurements were made in 75 healthy eyes and 73 eyes with POAG and correlations examined through Pearson correlation coefficients between the two sets of variables in the two subject groups. The corneal variables determined were corneal volume (CVol), central corneal thickness (CCT), overall corneal thickness (OvCT), the mean thickness of a circular zone centered at the corneal apex of 1 mm radius (zone I) and the mean thickness of several concentric rings, also centered at the apex until the limbus, each of 1 mm width (zones II to VI respectively). The ONH variables were determined using the HRT.
RESULTS: The following pairs of variables were correlated in the control group: CCT-disc area (DAr) (-0.48; P<0.0001), Zone I-DAr (-0.503; P<0.0001) and Zone II-DAr (-0.443; P<0.0001); and in the POAG group: CCT-cup-to-disc area ratio (CDRa) (-0.402; P<0.0001), Zone I-CDRa (-0.418; P<0.0001), Zone II-CDRa (-0.405; P=0.006), Zone I-cup shape measure (CSM) (-0.415; P=0.002), Zone II-CSM (-0.405; P=0.001), Zone IV-height variation contour (HVC) (0.378; P=0.002); Zone V-HVC (0.388, P<0.0001).
CONCLUSION: AS-OCT-derived lens thickness measurement is valid and comparable to the results obtained by A-scan US. It can be used as a reliable noncontact method for measuring lens thickness in adults with or without significant cataract.

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Uncontrolled Keywords:Glaucoma, Optic nerve head, Corneal thickness
Subjects:Medical sciences > Medicine > Diagnostic imaging and Nuclear medicine
Medical sciences > Medicine > Ophtalmology
ID Code:41312
Deposited On:17 Feb 2017 12:41
Last Modified:20 Feb 2017 11:51

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