Publication: Parámetros asociados a la eficacia de la pleurodesis y a la supervivencia en pacientes con derrame pleural maligno
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2017-02-20
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Universidad Complutense de Madrid
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Abstract
La pleurodesis química es una opción terapéutica para pacientes sintomáticos con derrame pleural maligno (DPM) y una expectativa de vida >2-3 meses. La guía americana sobre el manejo del DPM, en el año 2000, estableció los criterios de eficacia de la pleurodesis actualmente vigentes, por lo que muchos de los trabajos realizados sobre eficacia y factores predictores de respuesta a la pleurodesis, no siguen estas recomendaciones. En cuanto a la supervivencia en estos pacientes, existen datos contradictorios sobre los posibles factores asociados. HIPÓTESIS Y OBJETIVOS Hipótesis: Determinados parámetros pueden estar asociados a la eficacia clínico-radiológica de la pleurodesis o a la supervivencia en pacientes con DPM. Objetivos: Principales - Analizar las variables asociadas a la eficacia clínico-radiológica de la pleurodesis en pacientes con DPM, según el agente sinfisante utilizado: tetraciclina, doxiciclina y talco. - Analizar las variables asociadas a la supervivencia de los pacientes con DPM sometidos a pleurodesis. Secundarios - Conocer la eficacia de la pleurodesis, en pacientes con DPM, con los diferentes agentes sinfisantes utilizados: tetraciclina, doxiciclina y talco. - Describir las complicaciones de la pleurodesis...
Chemical pleurodesis is a therapeutic option for symptomatic patients with malignant pleural effusion (MPE) and a life expectancy greater than 2-3 months. The American guideline of MPE management, published in 2000, established the pleurodesis efficacy criteria currently in use. This is the reason why many studies about predictor factors and efficacy of pleurodesis, done earlier, did not use these criteria. Contradictory data exists about factors associated with survival in these patients. HYPOTHESIS AND OUTCOMES Hypothesis: Certain parameters can be associated with the clinical-radiological efficacy of pleurodesis or survival in patients with MPE. Outcomes: Primary outcomes - To analyze the variables associated with the clinical-radiological efficacy of pleurodesis in patients with MPE, according to the sclerosing agent used: tetracycline, doxycycline and talc. - To analyze the variables associated with survival of patients with MPE undergoing pleurodesis. Secondary outcomes - Know the effectiveness of pleurodesis, in patients with MPE, with the different sclerosing agents used: tetracycline, doxycycline and talc. - Describe the complications of pleurodesis...
Chemical pleurodesis is a therapeutic option for symptomatic patients with malignant pleural effusion (MPE) and a life expectancy greater than 2-3 months. The American guideline of MPE management, published in 2000, established the pleurodesis efficacy criteria currently in use. This is the reason why many studies about predictor factors and efficacy of pleurodesis, done earlier, did not use these criteria. Contradictory data exists about factors associated with survival in these patients. HYPOTHESIS AND OUTCOMES Hypothesis: Certain parameters can be associated with the clinical-radiological efficacy of pleurodesis or survival in patients with MPE. Outcomes: Primary outcomes - To analyze the variables associated with the clinical-radiological efficacy of pleurodesis in patients with MPE, according to the sclerosing agent used: tetracycline, doxycycline and talc. - To analyze the variables associated with survival of patients with MPE undergoing pleurodesis. Secondary outcomes - Know the effectiveness of pleurodesis, in patients with MPE, with the different sclerosing agents used: tetracycline, doxycycline and talc. - Describe the complications of pleurodesis...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 24/11/2015