A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants



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Macon, Anthony L. B. and Kim, Taek B. and Valliant, Esther M. and Goetschius, Kathryn and Brow, Richard K. and Day, Delbert E. and Hoppe, Alexander and Boccaccini, A. R. and Kim, Ill Yong and Ohtsuki, Chikara and Kokubo, Tadashi and Vallet Regí, María and Arcos Navarrete, Daniel and Fraile, Leandro and Salinas Sánchez, Antonio J. and Teixeira, Alexandra V. (2015) A unified in vitro evaluation for apatite-forming ability of bioactive glasses and their variants. Journal of Materials Science: Materials in Medicine, 26 (2). p. 115. ISSN 0957-4530

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The aim of this study was to propose and validate a new unified method for testing dissolution rates of bioactive glasses and their variants, and the formation of calcium phosphate layer formation on their surface, which is an indicator of bioactivity. At present, comparison in the literature is difficult as many groups use different testing protocols. An ISO standard covers the use of simulated body fluid on standard shape materials but it does not take into account that bioactive glasses can have very different specific surface areas, as for glass powders. Validation of the proposed modified test was through round robin testing and comparison to the ISO standard where appropriate. The proposed test uses fixed mass per solution volume ratio and agitated solution. The round robin study showed differences in hydroxyapatite nucleation on glasses of different composition and between glasses of the same composition but different particle size. The results were reproducible between research facilities. Researchers should use this method when testing new glasses, or their variants, to enable comparison between the literature in the future.

Item Type:Article
Additional Information:

RESEARCH ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez)
ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
ORCID 0000-0002-5367-7272 (Daniel Arcos Navarrete)
RESEARCHER ID L-6167-2014 (Daniel Arcos Navarrete)

Uncontrolled Keywords:Scaffolds, System, Growth, Hydroxyapatite, Dissolution, Implants, Behavior, Powders, 45S5, FTIR
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:41679
Deposited On:04 Apr 2017 10:10
Last Modified:04 Apr 2017 10:44

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