Mesoporous silica nanoparticles as a new carrier methodology in the controlled release of the active components in a polypill


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Doadrio Villarejo, Antonio Luis and Sánchez-Montero, José M. and Doadrio Villarejo, Juan Carlos and Salinas Sánchez, Antonio J. and Vallet Regí, María (2017) Mesoporous silica nanoparticles as a new carrier methodology in the controlled release of the active components in a polypill. European Journal of Pharmaceutical Sciences, 97 . pp. 1-8. ISSN 0928-0987

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Polypill is a medication designed for preventing heart attacks through a combination of drugs. Current formulations contain blood pressure-lowering drugs and others, such statins or acetylsalicylic acid. These drugs exhibit different physical chemical features, and consequently different release kinetics. Therefore, the concentration in plasma of some of them after the release process can be out of the therapeutic range. This paper investigates a new methodology for the control dosage of a polypill recently reported containing hydrochlorothiazide, amlodipine, losartan and simvastatin in a 12.5/2.5/25/40 weight ratio. The procedure is based onmesoporous silica nanoparticles (MSN) with MCM-41 structure (MSN-41) used as carrier, aimed to control release of the four drugs included in the polypill. In vitro release data were obtained by HPLC and the curves adjusted with a kinetic model. To explain the release results, a molecular model was built to determine the drug-matrix interactions, and quantum mechanical calculations were performed to obtain the electrostatic properties of each drug. Amlodipine, losartan and simvastatin were released from the polypill-MSN-41 system in a controlled way. This would be a favourable behavior when used clinically because avoid too quick pressure decrease. However, the diuretic hydrochlorothiazide was quickly released from our system in the first minutes, as is needed in hypertensive urgencies. In addition, an increase in the stability of amlodipine and hydrochlorothiazide occurred in the polypill-MSN-41 system. Therefore, the new way of polypill dosage proposed can result in a safer and effective treatment. (C) 2016 Elsevier B.V. All rights reserved.

Item Type:Article
Additional Information:

RESEARCH ID M-3378-2014 (María Vallet Regí)
ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez)
ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
ORCID 0000-0001-8380-4781 (Antonio Doadrio Villarejo)

Uncontrolled Keywords:Polypill; MCM-41 nanoparticles; Antihypertensive drugs; Cholesterol lowering; Diuretic
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:41687
Deposited On:18 Apr 2017 11:52
Last Modified:18 Apr 2017 12:05

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