Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol



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Arévalo, María Ángeles and Azcoitia Elías, Íñigo and González Burgos, Ignacio and García Segura, Luis Miguel (2015) Signaling mechanisms mediating the regulation of synaptic plasticity and memory by estradiol. Hormones and Behavior, 74 . pp. 19-27. ISSN 0018-506X

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Estradiol participates in the regulation of the function and plasticity of synaptic circuits in key cognitive brain regions, such as the prefrontal cortex and the hippocampus. The mechanisms elicited by estradiol are mediated by the regulation of transcriptional activity by nuclear estrogen receptors and by intracellular signaling cascades activated by estrogen receptors associated with the plasma membrane. In addition, the mechanisms include the interaction of estradiol with the signaling of other factors involved in the regulation of cognition, such as brain derived neurotrophic factor, insulin-like growth factor-1 and Wnt. Modifications in these signaling pathways by aging or by a long-lasting ovarian hormone deprivation after menopause may impair the enhancing effects of estradiol on synaptic plasticity and cognition.

Item Type:Article
Uncontrolled Keywords:Dendritic spines; Estrogen receptors; Growth factors; Hippocampus; Memory; Object recognition; Prefrontal cortex; Synaptic plasticity
Subjects:Medical sciences > Biology > Cytology
ID Code:41904
Deposited On:29 Mar 2017 11:50
Last Modified:08 May 2017 08:52

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