Short-term Effect of Scleral Lens on the Dry Eye Biomarkers in Keratoconus



Downloads per month over past year

Carracedo Rodríguez, Juan Gonzalo and Serramito Blanco, María and Martín Gil, Alba and Wang, Zicheng and Carballo Álvarez, Jesús and Pintor, Jesús (2016) Short-term Effect of Scleral Lens on the Dry Eye Biomarkers in Keratoconus. Optometry and Vision Science, 93 (2). pp. 150-157. ISSN 1040-5488

[thumbnail of Short term effect_OptVisScien-2015.pdf] PDF
Restringido a Repository staff only


Official URL:


Purpose: To evaluate the most important signs of dry eye, such as osmolarity, inflammation, and diadenosine tetraphosphate (Ap4A) concentration before and after wearing scleral lenses for 8 h in keratoconus patients.
Methods: A pilot, experimental, short-term study involved 26 keratoconus patients (average age, 36.95 ± 8.95 years). They voluntarily enrolled in the study at the Optometry Clinic of the Faculty of Optics and Optometry in the University Complutense of Madrid. They were divided into two groups: patients with intrastromal corneal ring, the ICRS group, and patients without ICRS, the keratoconus (KC) group. Ocular Surface Disease Index questionnaire, the Schirmer test without anesthesia, tear break-up time, matrix metalloproteinase 9 (MMP-9) concentration, osmolarity, and Ap4A concentration were evaluated before and after wearing a scleral lens for 8 h.
Results: The patients wore the scleral lenses from 6 to 9 h, with a mean of 7.59 ± 0.73 h. The mean scleral lens sag for all patients was 4310 ± 166.31 μm, ranging from 4200 μm to 4800 μm. No significant changes in the Schirmer test and tear break-up time were found for either group. Ocular Surface Disease Index scores were statistically lower after wearing scleral lenses for both groups (p < 0.05). A significantly lower osmolarity and a significant rise of MMP-9 concentration after wearing scleral lenses were found in both groups (p < 0.05). Diadenosine tetraphosphate concentration was lower after wearing the scleral lens in the KC group (p < 0.05) but no significant difference was found for the ICRS group (p > 0.05).
Conclusions: Short-term scleral lens wearing improves the symptomatology and some signs of dry eye, such as osmolarity and Ap4A concentration. The increase of MMP-9 concentration could be caused by tear film stagnation and use of preserved saline.

Item Type:Article
Additional Information:

Received June 14, 2015; accepted September 22, 2015.

Uncontrolled Keywords:Scleral lenses, Keratoconus, Nucleotides, MMP-9, Osmolarity
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Contact lenses
Medical sciences > Optics > Visual perception
ID Code:42130
Deposited On:07 Apr 2017 10:16
Last Modified:07 Apr 2017 11:05

Origin of downloads

Repository Staff Only: item control page