Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders



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Marco López, Eva María and Velarde, Elena and Llorente, Ricardo and Laviola, Giovanni (2016) Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders. Current Topics in Behavioral Neurosciences, 29 . pp. 155-181. ISSN 1866-3370

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The environment in which individuals develop and mature is critical for their physiological and psychological outcome; in particular, the intrauterine environment has reached far more clinical relevance given its potential influence on shaping brain function and thus mental health. Gestational stress and/or maternal infection during pregnancy has been related with an increased incidence of neuropsychiatric disorders, including depression and schizophrenia. In this framework, the use of animal models has allowed a formal and deep investigation of causal determinants. Despite disruption of circadian clocks often represents a hallmark of several neuropsychiatric disorders, the relationship between disruption of brain development and the circadian system has been scarcely investigated. Nowadays, there is an increasing amount of studies suggesting a link between circadian system malfunction, early-life insults and the appearance of neuropsychiatric diseases at adulthood. Here, we briefly review evidence from clinical literature and animal models suggesting that the exposure to prenatal insults, i.e. severe gestational stress or maternal immune activation, changes the foetal hormonal milieu increasing the circulating levels of both glucocorticoids and pro-inflammatory cytokines. These two biological events have been reported to affect genes expression in experimental models and critically interfere with brain development triggering and/or exacerbating behavioural anomalies in the offspring. Herein, we highlight the importance.

Item Type:Article
Uncontrolled Keywords:Early-life stress ; Prenatal ; Immune activation ; Animal models ; Clock genes
Subjects:Medical sciences > Biology
Medical sciences > Biology > Animal physiology
Medical sciences > Biology > Neurosciences
ID Code:42763
Deposited On:16 May 2017 16:10
Last Modified:18 May 2017 07:52

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