Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration



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Bari, Alessandra and Bloise, Nora and Fiorilli, Sonia and Novajra, Giorgia and Vallet Regí, María and Brunni, Giovanna and Torres Pardo, Almudena and González Calvet, J. M. and Visai, Libia and Vitale-Brovarone, Chiara (2017) Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration. Acta Biomaterialia, 55 . pp. 493-504. ISSN 1742-7061

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The application of mesoporous bioactive glasses (MBGs)containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure. The Cucontaining MBG (2% mol.) showed high exposed surface area (550 m2 g-1), uniform mesoporous channels (2.6 nm), remarkable in vitro bioactive behaviour and sustained release of Cu2+ ions.
Cu-MBG nanoparticles and their ionic dissolution extracts exhibited antibacterial effect against three different bacteria strains, E. coli, S. aureus, S. epidermidis, and the ability to inhibit and disperse the biofilm produced by S. epidermidis. The obtained results suggest that the developed material, which combines in single multifunctional agent excellent bioactivity and antimicrobial ability, offers promising opportunities for the prevention of infectious diseases and the effective treatment of bone defects.

Item Type:Article
Uncontrolled Keywords:Mesoporous bioactive glasses, Copper, Bone repair, Antibacterial activity, Biofilm
Subjects:Medical sciences > Pharmacy > Inorganic chemistry
ID Code:43053
Deposited On:02 Jun 2017 08:35
Last Modified:13 Apr 2019 23:01

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