Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

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Publication:
Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)

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Miguel. 2015. Neuroprotective role of sphingosine 1 phosphate in L BMAA treated neuroblastoma cells (SH-SY5Y).pdf (1.19 MB)

Official URL

https://www.journals.elsevier.com/neuroscience-letters/

Publication Date

2015-04-23

Authors

Muñoz Sáez, Emma

Munck García, Estefanía de

Arahuetes Portero, Rosa María

Scopus Author ID

Vicente, Francisca

Ortiz López, Francisco Javier

Cantizani, Juan

Gómez Miguel, Begoña

Scopus Author ID

Google Scholar ID

Publisher

Elsevier

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Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.

UCM subjects

Biología , Biología molecular (Biología)

Unesco subjects

24 Ciencias de la Vida , 2415 Biología Molecular

URI

https://hdl.handle.net/20.500.14352/23381

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