Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction



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Garzón Jiménez, Nuria and Poyales Galán, Francisco and Illarramendi, Igor and Mendicute, Javier and Jáñez, Oscar and Caro, Pedro and López, Alfredo and Argüeso Díaz-Trechuelo, Francisco (2016) Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction. International Ophthalmology . pp. 1-6. ISSN 0165-5701

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Purpose: to determine normative corneal densitometry values in relation to age, sex, refractive error, corneal thickness, and keratometry, measured using the Oculus Pentacam system.
Methods: three hundred and thirty-eight healthy subjects (185 men; 153 women) with no corneal disease underwent an exhaustive ocular examination. Corneal densitometry was expressed in standardized grayscale units (GSU).
Results: the mean corneal densitometry over the total area was 16.46 ± 1.85 GSU. The Pearson correlation coefficient for total densitometry was r = 0.542 (p < 0.001). Statistically significant differences were found between men and women for the total area (p = 0.006), with readings of 16.22 ± 1.54 GSU and 16.60 ± 1.83 GSU, respectively. When the cornea was divided into layers of different depths, a significant correlation was found for all layers and age: r = 0.447 (p < 0.001), r = 0.563 (p < 0.001), and r = 0.520 (p < 0.001) for the anterior, central, and posterior layers, respectively. However, when the cornea was divided into concentric annuli starting from the center of the cornea, densitometry was strongly correlated only with age in the 6–10-mm annulus (p < 0.001). Neither mean keratometry nor spherical equivalent was correlated with corneal densitometry in any zone of the cornea (p > 0.05).
Conclusions: this is the first report of normative corneal densitometry values in relation to keratometry, corneal thickness, and spherical equivalent measured with the latest Oculus Pentacam software. Corneal densitometry increases with age, but corneal keratometry and refractive parameters do not affect light scattering in the human cornea.

Item Type:Article
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Received: 31 August 2016 / Accepted: 7 November 2016

Uncontrolled Keywords:Corneal densitometry; Corneal transparency; Cornea
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Optometry
ID Code:43551
Deposited On:04 Jul 2017 11:27
Last Modified:04 Jul 2017 11:27

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