Publication: Uso de toxina botulímica paravertebral para detener la progresión de escoliosis en pollos pinealectomizados: la columna vertebral como sistema de tensegridad
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2017-08-18
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Universidad Complutense de Madrid
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Abstract
La escoliosis idiopática infantil no tiene un tratamiento satisfactorio que permita reducir la importante morbilidad y mortalidad asociada a los casos más severos y progresivos de la enfermedad. Independientemente de su origen, se postula que las curvas de escoliosis presentan una debilidad estructural de partes blandas en el lado de la convexidad de la curva. Trabajos previos subrayan la capacidad de la pinealectomía en pollos de experimentación para producir escoliosis, como modelo de estudio de la enfermedad. Por otro lado, la toxina botulínica se ha usado ampliamente con resultados satisfactorios y un perfil de bioseguridad demostrado en la población pediátrica. Objetivo El objetivo principal del estudio es valorar la influencia de la toxina botulínica, inyectada de forma unilateral en la musculatura paravertebral de la concavidad de la deformidad, en la progresión de las curvas de escoliosis de pollos pinealectomizados...
Severe and progressive idiopathic scoliosis has no satisfactory treatment since high rates of morbidity and mortality are associated. Regardless of its etiology, it́s assumed that scoliosis curves show a soft tissue structural weakness at the convexity side. Previous works highlight pinealectomy as a reliable method to induce scoliosis in chickens, as an animal model to study such disease. On the other hand, botulinum toxin has been widely used with satisfactory results and a proven biosafety profile in children. Objective The main objective of this study is the assessment of botulinum toxin influence, injected unilaterally in the paravertebral muscles of the deformitýs concave side, in the scoliosis curve progression in pinealectomized chickens...
Severe and progressive idiopathic scoliosis has no satisfactory treatment since high rates of morbidity and mortality are associated. Regardless of its etiology, it́s assumed that scoliosis curves show a soft tissue structural weakness at the convexity side. Previous works highlight pinealectomy as a reliable method to induce scoliosis in chickens, as an animal model to study such disease. On the other hand, botulinum toxin has been widely used with satisfactory results and a proven biosafety profile in children. Objective The main objective of this study is the assessment of botulinum toxin influence, injected unilaterally in the paravertebral muscles of the deformitýs concave side, in the scoliosis curve progression in pinealectomized chickens...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Cirugía, leída el 18-01-2016