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Conde Montero, Elena (2017) Validación de un nuevo método de obtención de plasma rico en plaquetas para su aplicación en úlceras cutáneas crónicas. [Thesis]
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Abstract
El plasma rico en plaquetas (PRP) es una técnica utilizada en diferentes campos de la medicina con la función de mejorar la regeneración tisular. En dermatología, sus principales aplicaciones en los últimos años han sido el campo de la estética, sobre todo el tratamiento anti-envejecimiento, y la cicatrización de heridas. El PRP se define por contener una mayor concentración de plaquetas que la sangre total, por lo que representa un reservorio de factores de crecimiento. Las heridas crónicas se caracterizan por presentar una fase inflamatoria anormalmente prolongada, que implica una destrucción continuada de proteínas de matriz y factores de crecimiento. Los factores de crecimiento estimulan la migración, proliferación y diferenciación celular, que son fundamentales en el proceso de cicatrización. Ante el reto terapéutico que representan las úlceras cutáneas crónicas en nuestra práctica clínica diaria, el PRP representa una interesante alternativa de tratamiento, cuya eficacia ha sido demostrada in vitro e in vivo. En los últimos años se han publicado y comercializado diversos métodos para obtener PRP, que implican el uso de kits desechables, de coste variable...
Resumen (otros idiomas)
Platelet rich plasma (PRP) is a widespread technique throughout diverse fields of Medicine for improving tissue regeneration. In dermatology, the main applications during the last years have mainly been anti-aging treatments and wound healing. PRP contains platelets in higher concentration than whole blood and, consequently, represents a growth factor pool. Chronic wounds are characterized by a prolonged inflammatory phase, involving a continuous destruction of matrix proteins and growth factors. Growth factors promote cell migration, proliferation and differentiation, which are essential for wound healing. Regarding the therapeutic challenge that chronic ulcers represent in our daily clinical practice, PRP may be considered a suitable treatment option, whose efficacy has been proven both in vivo and in vitro. In the last years, several methods for obtaining PRP have been published and commercialized, with disposal kits at different prices. Products from these commercially available systems produce differing concentration of growth factors and other bioactive molecules. Moreover, different techniques have been suggested to obtain PRP gel for topical application, such as healing during non-negligible time. In our department, we have created a compassionate protocol in order to treat chronic cutaneous ulcers with PRP, which we obtain with economic material and an easily reproducible technique. In addition to these advantages, the polymer that we propose for gelification enables an immediate production of PRP gel. The benefits of our method are key points when considering including PRP treatment in our daily clinical practice...
| Item Type: | Thesis |
|---|---|
| Additional Information: | Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Medicina, leída el 08-04-2016 |
| Directors: | Directors Martínez González, José María Suárez Fernández, Ricardo Millán Núñez-Cortés, Jesús |
| Uncontrolled Keywords: | Piel, úlceras |
| Palabras clave (otros idiomas): | Skin, ulcers |
| Subjects: | Medical sciences > Medicine > Dermatology |
| ID Code: | 44375 |
| Deposited On: | 29 Aug 2017 09:29 |
| Last Modified: | 29 Aug 2017 09:29 |
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