Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population



Downloads per month over past year

Fernández Vigo, José Ignacio and García Feijoo, Julián and Martínez de la Casa, Jose Maria and García Bella, Javier and Arriola Villalobos, Pedro and Fernández Pérez, Cristina and Fernández Vigo, José Ángel (2016) Fourier domain optical coherence tomography to assess the iridocorneal angle and correlation study in a large Caucasian population. BMC Ophthalmology, 16 (42). 7 p.. ISSN 1471-2415

[thumbnail of fourier domain-BMC Opth-2016.pdf]
Creative Commons Attribution Non-commercial.


Official URL:


Background: Recently, novel anatomic parameters that can be measured by optical coherence tomography (OCT), have been identified as a more objective and accurate method of defining the iridocorneal angle. The aim of the present study is to measure the iridocorneal angle by Fourier domain (FD) OCT and to identify correlations between angle measurements and subject factors in a large healthy Caucasian population.
Methods: A cross sectional study was performed in 989 left eyes of 989 healthy subjects. The iridocorneal angle measurements: trabecular-iris angle (TIA), angle opening distance (AOD500) and trabecular-iris space area (TISA500) 500 μm from the scleral spur, were made using the FD-OCT RTVue®. Iris thickness was also measured. Correlations were examined between angle measurements and demographic and ocular factors. The main determinants of angle width were identified by multivariate linear regression.
Results: TIA could be measured in 94 % of the eyes, and AOD500 and TISA500 in 92 %. The means recorded were TIA 35.8 ± 12.2 degrees (range 1.5 to 76.1), AOD500 542.6 ± 285.4 μm (range 15 to 1755), and TISA500 0.195 ± 0.104 mm2 (range 0.02 to 0.62). The correlation between the temporal and nasal quadrant was R = 0.902 for TIA. The reproducibility of measurements was excellent (intraclass correlation coefficient >0.947). Mean angle width measurements were smaller in women (p = 0.02). Correlation was detected between angle means and anterior chamber volume (ACV; R = 0.848), anterior chamber depth (ACD; R = 0.818), spherical error (R = -0.619) and age (R = -0.487), while no correlation was observed with Intraocular pressure (R = -0.052). ACV emerged as the main determinant of TIA (R2 = 0.705; p < 0.001).
Conclusions: In this Caucasian population, strong correlation was detected between FD-OCT anterior angle measurements and ACV, ACD, spherical refractive error and sex, emerging the ACV as the main determinant of TIA.

Item Type:Article
Additional Information:

Revista en O.A.

Uncontrolled Keywords:Anterior chamber, Iridocorneal angle, Glaucoma, Optical coherence tomography
Subjects:Medical sciences > Medicine > Ophtalmology
Medical sciences > Optics > Imaging systems
ID Code:44478
Deposited On:14 Sep 2017 12:30
Last Modified:14 Sep 2017 12:30

Origin of downloads

Repository Staff Only: item control page