Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs



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Lizarbe, María Antonia and Calle Espinosa, Jorge and Fernández Lizarbe, Eva and Fernández Lizarbe, Sara and Robles, Miguel Ángel and Olmo López, Nieves and Turnay, Javier (2017) Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs. BioMed Research International, 2017 (735426). pp. 1-39. ISSN 2314-6133, ESSN: 2314-6141

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Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved. In addition, noncoding RNAs have been shown to be important regulators of gene expression. We present a general overview of what is known about these molecules and their role and dysregulation in cancer, with a special focus on the biogenesis, characteristics, and function of microRNAs. These molecules are important regulators of carcinogenesis, progression, invasion, angiogenesis, and metastases in cancer, including colorectal cancer. For this reason, miRNAs can be used as potential biomarkers for diagnosis, prognosis, and efficacy of chemotherapeutic treatments, or even as therapeutic agents, or as targets by themselves. Thus, this review highlights the importance of miRNAs in the development, progression, diagnosis, and therapy of colorectal cancer and summarizes current therapeutic approaches for the treatment of colorectal cancer.

Item Type:Article
Uncontrolled Keywords:Colorectal Cancer; Biomarkers; RNAs
Subjects:Medical sciences > Medicine > Biochemistry
Medical sciences > Medicine > Oncology
Medical sciences > Biology > Genetics
ID Code:44687
Deposited On:18 Sep 2017 10:29
Last Modified:18 Sep 2017 10:48

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