Lysine-Grafted MCM-41 Silica as An Antibacterial Biomaterial



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Villegas, Fernanda and Garcia-Uriostegui, Lorena and Rodríguez, Ofelia and Izquierdo-Barba, Isabel and Salinas Sánchez, Antonio J. and Toriz, Guillermo and Vallet Regí, María and Delgado, Ezequiel (2017) Lysine-Grafted MCM-41 Silica as An Antibacterial Biomaterial. Bioengineering, 4 . p. 80. ISSN 2306-5354; CODEN: BIOEBG

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Abstract: A facile strategy for zwitterionization of bioceramics based on direct incorporation of L-lysine amino acid via the ε-amino group onto mesoporous MCM-41 materials is proposed. FTIR studies of lysine-grafted MCM-41 (MCM-LYS) showed simultaneously bands at 3080 and 1540 cm−1 and bands at 1625 and 1415 cm−1 corresponding to -NH3+/COO− pairs, demonstrating the incorporation of the amino acid on the material surface keeping its zwitterionic character. Both elemental and thermogravimetric analyses showed that the amount of grafted lysine was 8 wt % based on the bioceramic total weight. Moreover, MCM-LYS material exhibited a reduction of adhesion of S. aureus and E. coli bacteria in 33 and 50%, respectively at physiological pH, as compared with pristine MCM-41. Biofilm studies onto surfaces showed that lysine functionalization elicited a reduction of the area covered by S. aureus biofilm from 42% to only 5% (88%). This research shows a simple and effective approach to chemically modify bioceramics using single amino acids that provide zwitterionic functionality, useful to develop new biomaterials able to resist bacterial adhesion.

Item Type:Article
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ORCID 0000-0002-6104-4889 (María Vallet Regí)
RESEARCHER ID M-3378-2014 (María Vallet Regí)

Uncontrolled Keywords:Lysine grafting, Zwitterionization, Mesoporous MCM-41 biomaterial, Antibacterial adhesion; biofilm formation
Subjects:Sciences > Chemistry > Chemical engineering
Sciences > Chemistry > Chemistry, Inorganic
ID Code:44871
Deposited On:02 Nov 2017 11:11
Last Modified:02 Nov 2017 16:02

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