Publication: Estudio de la función neuropsicológica y de loa genes APOE, NRG1, BACE1 y ERBB4 en la discriminación cuantitativa y cualitativa del deterioro cognitivo
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2017-10-04
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Universidad Complutense de Madrid
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Abstract
Durante los próximos 30 años, el porcentaje de personas de 65 años o más aumentará del 17% al 30%, y el porcentaje de personas mayores de 80 años aumentará del 5% al 12%. La capacidad cognitiva de las personas mayores y la disminución cognitiva relacionada con la edad han sido los factores que más se han considerado para el estudio de los endofenotipos cognitivos durante el envejecimiento normal. La capacidad cognitiva que más frecuentemente se ve afectada por la edad y la enfermedad es la memoria. La memoria es el medio por el cual se mantienen y en el cual se apoyan nuestras experiencias pasadas para así poder utilizar esa información en el presente. Las personas son conscientes de sus fallos de memoria al inicio de un deterioro cognitivo pero la propia evaluación subjetiva del individuo sobre el funcionamiento de su memoria puede no reflejar una valoración exacta de la existencia de un déficit de memoria real. En 1995, Petersen et al. describen una nueva entidad nosológica, el deterioro cognitivo ligero (DCL). El DCL engloba a aquellos individuos que sin presentar una demencia presentarían una alteración cognitiva. Existe un solapamiento del DCL con respecto a la normalidad y a la demencia, de tal manera que las personas con DCL más leve serían difícilmente diferenciables de aquellos, que aunque normales, tuvieran un peor rendimiento cognitivo...
Over the next 30 years, the percentage of persons aged 65 and older will increase from 17% to 30%, and the percentage of people over 80 will rise from 5% to 12%. The cognitive abilities of the elderly and related cognitive decline with age were the factors that were considered for the study of cognitive endophenotypes during normal aging. The cognitive ability that more frequently is affected by age and disease is memory. Memory is the medium through which remain and where will support our past experiences in order to use that information in the present. People are aware of their memory lapses at the start of a cognitive impairment but the subjective evaluation of the individual over the operation of memory itself can not reflect an accurate assessment of the existence of a deficit of real memory. In 1995, Petersen et al. describe a new disease entity, mild cognitive impairment (MCI). The MCI includes individuals who have a cognitive impairment in absence of dementia. There is an overlap of MCI with respect to normality and dementia, so that people with slighter MCI would hardly distinguishable from those although normal had a worse cognitive performance. Also it occurs when there was a more severe MCI and a mild dementia. MCI is a pre-Alzheimer's Disease (AD) and according to the study’s findings of Petersen et al. 2001, AD conversion rate is approximately 12%...
Over the next 30 years, the percentage of persons aged 65 and older will increase from 17% to 30%, and the percentage of people over 80 will rise from 5% to 12%. The cognitive abilities of the elderly and related cognitive decline with age were the factors that were considered for the study of cognitive endophenotypes during normal aging. The cognitive ability that more frequently is affected by age and disease is memory. Memory is the medium through which remain and where will support our past experiences in order to use that information in the present. People are aware of their memory lapses at the start of a cognitive impairment but the subjective evaluation of the individual over the operation of memory itself can not reflect an accurate assessment of the existence of a deficit of real memory. In 1995, Petersen et al. describe a new disease entity, mild cognitive impairment (MCI). The MCI includes individuals who have a cognitive impairment in absence of dementia. There is an overlap of MCI with respect to normality and dementia, so that people with slighter MCI would hardly distinguishable from those although normal had a worse cognitive performance. Also it occurs when there was a more severe MCI and a mild dementia. MCI is a pre-Alzheimer's Disease (AD) and according to the study’s findings of Petersen et al. 2001, AD conversion rate is approximately 12%...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, Departamento de Psiquiatría, leída el 25-01-2016