A novel visible light responsive nanosystem for cancer treatment



Downloads per month over past year

Martínez Carmona, Marina and Lozano Borregón, Daniel and Baeza, Alejandro and Colilla, Montserrat and Vallet Regí, María (2017) A novel visible light responsive nanosystem for cancer treatment. Nanoscale (9). pp. 15967-15973. ISSN 2040-3372

[thumbnail of Nanoscale.pdf]

Official URL: http://www.rsc.org/


A novel singlet-oxygen sensitive drug delivery nanocarrier able to release their cargo after exposure to visible (Vis) light of a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In presence of Vis light the porphyrinnanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of thE non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the seeking for new alternatives for the treatment of cancer.

Item Type:Article
Uncontrolled Keywords:Cancer treatment, Mesoporous silica nanoparticles (MSN), Singlet oxygen molecules
Subjects:Sciences > Chemistry > Materials
Sciences > Chemistry > Chemistry, Inorganic
ID Code:45134
Deposited On:03 Nov 2017 12:42
Last Modified:20 Sep 2018 23:01

Origin of downloads

Repository Staff Only: item control page