Publication: Impacto del tratamiento periodontal básico en los niveles de porphyronomas gingivalis y Aggregatibacter actinomycetemcomitans a nivel local y su relación con la enfermedad cardiovascular: Estudio piloto a 6 meses
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2017
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Ante la presencia de evidencia científica suficiente que apoya la asociación de las enfermedades cardiovasculares y las enfermedades periodontales, y las dificultades existentes a la hora de realizar estudios de intervención que permitan evaluar los beneficios del tratamiento periodontal en la enfermedad cardiovascular, se propone el siguiente ensayo clínico de 6 meses de duración con pacientes con antecedentes de síndrome coronario agudo ocurrido hace menos de un año y con periodontitis crónica moderada-avanzada, donde el grupo test recibe tratamiento periodontal básico en 2 días consecutivos junto con enjuagues con clorhexidina durante diez días, mientras el grupo control recibe una profilaxis dental acompañado de enjuagues con flúor durante diez días.
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• AAP 1996. Consensus report. Periodontal diseases: pathogenesis and microbial factors. Ann Periodontol, 1, 926-32.
• Armitage, G. C. 1999. Development of a Classification System for Periodontal Diseases and Conditions. Ann Periodontol, 4.
• Baheni, P. & Tonetti, M. S. 2010. Conclusions and consensus statements on periodontal health, policy and education in Europe: a call for action--consensus view 1. Consensus report of the 1st European Workshop on Periodontal Education. Eur J Dent Educ, 14 Suppl 1, 2-3.
• Bahekar, A. A., Singh, S., Saha, S., Molinar, J. & Arora, R. 2007. The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis. Am Heart J, 154, 830-7.
• Beck, J. D. & Offenbacher, S. 2005. Systemic effects of periodontitis: epidemiology of periodontal disease and cardiovascular disease. J Periodontol, 76, 2089-100.
• Blaizot, A., Vergnes, J. N., Nuwwareh, S., Amar, J. & Sixou, M. 2009. Periodontal diseases and cardiovascular events: meta-analysis of observational studies. Int Dent J, 59, 197-209.
• Blum, A., Kryuger, K., Mashiach Eizenberg, M., Tatour, S., Vigder, F., Laster, Z. & Front, E. 2007. Periodontal care may improve endothelial function. Eur J Intern Med, 18, 295-8.
• Bokhari, S. A., Khan, A. A., Butt, A. K., Azhar, M., Hanif, M., Izhar, M. & Tatakis, D.
N. 2012. Non-surgical periodontal therapy reduces coronary heart disease risk markers: a randomized controlled trial. J Clin Periodontol, 39, 1065-74.
• Braunwald, E. 1996. Acute myocardial infarction--the value of being prepared. N Engl J Med, 334, 51-2.
• Buckley, D. I., Fu, R., Freeman, M., Rogers, K. & Helfand, M. 2009. C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta- analyses for the U.S. Preventive Services Task Force. Ann Intern Med, 151, 483-95.
• Calapkorur, M. U., Alkan, B. A., Tasdemir, Z., Akcali, Y. & Saatci, E. 2016. Association of peripheral arterial disease with periodontal disease: analysis of inflammatory cytokines and an acute phase protein in gingival crevicular fluid and serum. J Periodontal Res, 1-8.
• Cannon, C. P., Braunwald, E., Mccabe, C. H., Grayston, J. T., Muhlestein, B., Giugliano, R. P., Cairns, R. & Skene, A. M. 2005. Antibiotic treatment of Chlamydia pneumoniae after acute coronary syndrome. N Engl J Med, 352, 1646-54.
• Carasol, M., Llodra, J. C., Fernandez-Meseguer, A., Bravo, M., García-Margallo, M. T., Calvo-Bonacho, E., Sanz, M. & Herrera, D. 2016. Periodontal conditions among employed adults in Spain. J Clin Periodontol, 43, 548-56.
• Carrion, J., Scisci, E., Miles, B., Sabino, G. J., Zeituni, A. E., Gu, Y., Bear, A., Genco, C. A., Brown, D. L. & Cutler, C. W. 2012. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J Immunol, 189, 3178-87.
• Castro Lara, J., Ibero Sagastibela. I., Bascones Martínez, A. 2001. ¿Es la enfermedad periodontal un factor de riesgo para las enfermedades cardiovasculares? (I) Etiopatogenia y ensayos clinicos. Avances en periodoncia, 13, 65-75.
• Caula, A. L., Lira-Junior, R., Tinoco, E. M. & Fischer, R. G. 2014. The effect of periodontal therapy on cardiovascular risk markers: a 6-month randomized clinical trial. J Clin Periodontol, 41, 875-82.
• Cobb, C. M. 1996. Non-surgical pocket therapy: mechanical. Ann Periodontol, 1, 443-90.
• Chapple, I. L. & Genco, R. 2013. Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol, 40 Suppl 14, S106-12.
• Chou, H. H., Yumoto, H., Davey, M., Takahashi, Y., Miyamoto, T., Gibson, F. C. 3rd &
Genco, C. A. 2005. Porphyromonas gingivalis fimbria-dependent activation of inflammatory genes in human aortic endothelial cells. Infect Immun, 73, 5367-78.
• Chukkapalli, S. S., Velsko, I. M., Rivera-Kweh, M. F., Larjava, H., Lucas, A. R. & Kesavalu, L. 2017. Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection. Mol Oral Microbiol, 32, 211-225.
• Chun, Y. H., Chun, K. R., Olguin, D. & Wang, H. L. 2005. Biological foundation for periodontitis as a potential risk factor for atherosclerosis. J Periodontal Res, 40, 87- 95.
• De Teresa, E., López Salguero, J. R., Molero, E. & Cruz, J. M. 2003. Formas de presentación clínica de la cardiopatía isquémica. Angina estable, angina inestabe e infarto de miocardio. In: De Teresa, E. (ed.) Miocardiopatía isquémica. Madrid: Cardiología en Atención Primaria. Aula Medica Ediciones.
• De Teresa, E. & Noguerol, B. 2011. Inflamación y cardiopatia isquémica. In: PANAMERICANA, E. M. (ed.) Patología Periodontal y Cardiovascular. Madrid: SEPA y SEC.
• Deanfield, J. E., Halcox, J. P. & Rabelink, T. J. 2007. Endothelial function and dysfunction: testing and clinical relevance. Circulation, 115, 1285-95.
• Elter, J. R., Hinderliter, A. L., Offenbacher, S., Beck, J. D., Caughey, M., Brodala, N.
& Madianos, P. N. 2006. The effects of periodontal therapy on vascular endothelial function: a pilot trial. Am Heart J, 151, 47.
• Fadini, G. P., Pagano, C., Baesso, I., Kotsafti, O., Doro, D., De Kreutzenberg, S. V., Avogaro, A., Agostini, C. & Dorigo, M. T. 2010. Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma. Acta Ophthalmol, 88, 135-41.
• Figuero, E., Lindahl, C., Marin, M. J., Renvert, S., Herrera, D., Ohlsson, O., Wetterling, T. & Sanz, M. 2014. Quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. J Periodontol, 85, 1182-93.
• Figuero, E., Sánchez-Beltran, M., Cuesta-Frechoso, S., Tejerina, J. M., Del Castro, J. A., Gutiérrez, J. M., Herrera, D. & Sanz, M. 2011. Detection of periodontal bacteria in atheromatous plaque by nested polymerase chain reaction. J Periodontol, 82, 1469-77.
• Fuster, V. 1994. Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation, 90, 2126-46.
• Gunsolley, J. C. 2006. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc, 137, 1649-57.
• Gunsolley, J. C. 2010. Clinical efficacy of antimicrobial mouthrinses. J Dent, 38 Suppl 1, S6-10.
• Haffajee, A. D. & Socransky, S. S. 1994. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000, 5, 78-111.
• Hajishengalis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., Darveau, R. P. & Curtis,
M. A. 2011. Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement. Cell Host Microbe, 10, 497-506.
• Hamburg, N. M. & Benjamin, E. J. 2009. Assessment of endothelial function using digital pulse amplitude tonometry. Trends Cardiovasc Med, 19, 6-11.
• Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M. & Genco, R. J. 2000. Identification of periodontal pathogens in atheromatous plaques. J Periodontol, 71, 1554-60.
• Hashizume, T., Kurita-Ochiai, T. & Yamamoto, M. 2011. Porphyromonas gingivalis stimulates monocyte adhesion to human umbilical vein endothelial cells. FEMS Immunol Med Microbiol, 62, 57-65.
• Haubek, D., Ennibi, O. K., Poulsen, K., Vaeth, M., Poulsen, S. & Kilian, M. 2008. Risk of aggressive periodontitis in adolescent carriers of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans in Morocco: a prospective longitudinal cohort study. Lancet, 371, 237-42.
• Hayashi, C., Viereck, J., Hua, N., Phinikaridou, A., Madrigal, A. G., Gibson, F. C. 3rd
Hamilton, J. A. & Genco, C. A. 2011. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis, 215, 52-9.
• Helfand, M., Buckley, D. I., Freeman, M., FU, R., Rogers, K., Fleming, C. & Humphrey, L. L. 2009. Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task Force. Ann Intern Med, 151, 496-507.
• Hujoel, P. P., Drangsholt, M., Spiekerman, C. & Derouen, T. A. 2002. Periodontitis- systemic disease associations in the presence of smoking--causal or coincidental? Periodontol 2000, 30, 51-60.
• Ide, M., McPartlin, D., Coward, P. Y., Crook, M., Lumb, P. & Wilson, R. F. 2003. Effect of treatment of chronic periodontitis on levels of serum markers of acute- phase inflammatory and vascular responses. J Clin Periodontol, 30, 334-40.
• James, P., Worthington, H. V., Parnell, C., Harding, M., Lamont, T., Cheung, A., Whelton, H. & Riley, P. 2017. Chlorhexidine mouthrinse as an adjunctive treatment for gingival health. Cochrane Database Syst Rev, 3.
• Jayaprakash, K., Khalaf, H. & Bengtsson, T. 2014. Gingipains from Porphyromonas gingivalis play a significant role in induction and regulation of CXCL8 in THP-1 cells. BMC Microbiol, 14, 193.
• Kaptoge, S., Di Angelantonio, E., Lowe, G., Pepys, M. B., Thompson, S. G., Collins,
R. & Danesh, J. 2010. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet, 375, 132-40.
• Kassebaum, N. J., Bernabe, E., Dahiya, M., Bhandari, B., Murray, C. J. & Marcenes,
W. 2014. Global burden of severe periodontitis in 1990-2010: a systematic review and meta-regression. J Dent Res, 93, 1045-53.
• Khazaei, M., Moien-Afshari, F. & Laher, I. 2008. Vascular endothelial function in health and diseases. Pathophysiology, 15, 49-67.
• Koppolu, P., Durvasula, S., Palaparthy, R., Rao, M., Sagar, V., Reddy, S. K. & Lingam,
S. 2013. Estimate of CRP and TNF-alpha level before and after periodontal therapy in cardiovascular disease patients. Pan Afr Med J, 15, 1-10.
• Koren, O., Spor, A., Felin, J., Fak, F., Stombaugh, J., Tremaroli, V., Behre, C. J., Knight, R., Fagerberg, B., Ley, R. E. & Backhed, F. 2011. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A, 108 Suppl 1, 4592-8.
• Korman, K. S. 2008. Mapping the pathogenesis of periodontitis: a new look. J Periodontol, 79, 1560-8.
• Lang, N. P., Bartold, M., Cullinan, M., Jeffcoat, M., Mombelli, A., Murakami, S., Page, R. C., Papapanou, P. N., Tonetti, M. & Van Dyke, T. E. 1999. Consensus Report: Aggressive Periodontitis. Ann Periodontol, 4.
• Lang, N. P., Tan, W. C., Krahenmann, M. A. & Zwahlen, M. 2008. A systematic review of the effects of full-mouth debridement with and without antiseptics in patients with chronic periodontitis. J Clin Periodontol, 35, 8-21.
• Lei, L., Li, H., Yan, F., Li, Y. & Xiao, Y. 2011. Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low- density-lipoprotein-induced macrophages and foam cells. J Periodontal Res, 46, 427-37.
• Leng, W. D., Zeng, X. T., Kwong, J. S. & Hua, X. P. 2015. Periodontal disease and risk of coronary heart disease: An updated meta-analysis of prospective cohort studies. Int J Cardiol, 201, 469-72.
• Li, X., Tse, H. F., Yiu, K. H., Li, L. S. & Jin, L. 2011. Effect of periodontal treatment on circulating CD34(+) cells and peripheral vascular endothelial function: a randomized controlled trial. J Clin Periodontol, 38, 148-56.
• Libby, P., Ridker, P. M. & Maseri, A. 2002. Inflammation and atherosclerosis.
Circulation, 105, 1135-43.
• Lindhe, J., Ranney, R., Lamster, I., Charles, A., Chung, C. P., Flemming, T., Kinane, D., Listgarten, M., Löe, H., Schoor, R., Seymour, G. & Somerman, M. 1999. Consensus Report: Chronic Periodontitis. Ann Periodontol, 4.
• Lockhart, P. B., Bolger, A. F., Papapanou, P. N., Osinbowale, O., Trevisan, M., Levison, M. E., Taubert, K. A., Newburger, J. W., Gornik, H. L., Gewitz, M. H., Wilson, W. R., Smith, S. C. Jr. & Baddour, L. M. 2012. Periodontal disease and atherosclerotic vascular disease: does the evidence support an independent association?: a scientific statement from the American Heart Association. Circulation, 125, 2520-44.
• Lockhart, P. B., Brennan, M. T., Sasser, H. C., Fox, P. C., Paster, B. J. & Bahrani- Mougeout, F. K. 2008. Bacteremia associated with toothbrushing and dental extraction. Circulation, 117, 3118-25.
• López, N. J., Quintero, A., Casanova, P. A. & Martínez, B. 2014. Routine prophylaxes every 3 months improves chronic periodontitis status in type 2 diabetes. J Periodontol, 85, e232-40.
• Llodra Calvo, J. C. 2010. Encuesta de Salud Oral en España 2010. Enero 2012 ed. España: RCOE.
• Martín, B. J. & Anderson, T. J. 2009. Risk prediction in cardiovascular disease: the prognostic significance of endothelial dysfunction. Can J Cardiol, 25 Suppl A, 15a- 20a.
• Matsuzawa, Y., Kwon, T. G., Lennon, R. J., Lerman, L. O. & Lerman, A. 2015. Prognostic Value of Flow-Mediated Vasodilation in Brachial Artery and Fingertip Artery for Cardiovascular Events: A Systematic Review and Meta-Analysis. J Am Heart Assoc, 4.
• Mattila, K. J., Niemnen, M. S., Valtonen, V. V., Rasi, V. P., Kesaniemi, Y. A., Syrjala,
S. L., Jungell, P. S., Isoluoma, M., Hietaniemi, K. & Jokinen, M. J. 1989. Association between dental health and acute myocardial infarction. Bmj, 298, 779-81.
• Meurman, J. H., Sanz, M. & Janket, S. J. 2004. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med, 15, 403-13.
• Norgren, L., Hiatt, W. R., Dormandy, J. A., Nehler, M. R., Harris, K. A., Fowkes, F. G.
& Rutherford, R. B. 2007. Inter-society consensus for the management of peripheral arterial disease. Int Angiol, 26, 81-157.
• Offenbacher, S., Beck, J. D., Moss, K., Mendoza, L., Paquette, D. W., Barrow, D. A., Couper, D. J., Stewart, D. D., Falkner, K. L., Graham, S. P., Grossi, S., Gunsolley, J. C., Madden, T., Maupome, G., Trevisan, M., Van Dyke, T. E. & Genco, R. J. 2009. Results from the Periodontitis and Vascular Events (PAVE) Study: a pilot multicentered, randomized, controlled trial to study effects of periodontal therapy in a secondary prevention model of cardiovascular disease. J Periodontol, 80, 190- 201.
• Offenbacher S, W. R., Champagne C. 1996. Oral biofilms in health and disease,
Cardiff.
• Page, R. C. & Korman, K. S. 1997. The pathogenesis of human periodontitis: an introduction. Periodontol 2000, 14, 9-11.
• Paraskevas, S., Huizinga, J. D. & Loos, B. G. 2008. A systematic review and meta- analyses on C-reactive protein in relation to periodontitis. J Clin Periodontol, 35, 277-90.
• Pathirana, R. D., O'brien-Simpson, N. M. & Reynolds, E. C. 2010. Host immune responses to Porphyromonas gingivalis antigens. Periodontol 2000, 52, 218-37.
• Piconi, S., Trabattoni, D., Luraghi, C., Perilli, E., Borelli, M., Pacei, M., Rizzardini, G., Lattuada, A., Bray, D. H., Catalano, M., Sparaco, A. & Clerici, M. 2009. Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness. Faseb j, 23, 1196-204.
• Preshaw, P. M. & Taylor, J. J. 2011. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol, 38 Suppl 11, 60-84.
• Quirynen, M., Bollen, C. M., Vandekerckhove, B. N., Dekeyser, C., Papaiannou, W.
& Eyssen, H. 1995. Full- vs. partial-mouth disinfection in the treatment of periodontal infections: short-term clinical and microbiological observations. J Dent Res, 74, 1459-67.
• Ras, R. T., Streppel, M. T., Draijer, R. & Zock, P. L. 2013. Flow-mediated dilation and cardiovascular risk prediction: a systematic review with meta-analysis. Int J Cardiol, 168, 344-51.
• Reyes, L., Herrera, D., Kozarov, E., Rolda, S. & Progulske-Fox, A. 2013. Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology. J Periodontol, 84, S30-50.
• Rivera, M. F., Lee, J. Y., Aneja, M., Goswami, V., Liu, L., Velsko, I. M., Chukkapalli, S. S., Bhattacharyya, I., Chen, H., Lucas, A. R. & Kesavalu, L. N. 2013. Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One, 8, e57178.
• Ross, R. 1999. Atherosclerosis--an inflammatory disease. N Engl J Med, 340, 115- 26.
• Salvi, G. E., Carollo-Bittel, B. & Lang, N. P. 2008. Effects of diabetes mellitus on periodontal and peri-implant conditions: update on associations and risks. J Clin Periodontol, 35, 398-409.
• Sanz, I., Alonso, B., Carasol, M., Herrera, D. & Sanz, M. 2012. Nonsurgical treatment of periodontitis. J Evid Based Dent Pract, 12, 76-86.
• Sanz, M., Beighton, D., Curtis, M. A., Cury, J. A., Dige, I., Dommisch, H., Ellwood, R., Giacaman, R., Herrera, D., Herzberg, M. C., Kononen, E., Marsh, P. D., Meyle, J., Mira, A., Molina, A., Mombelli, A., Quirynen, M., Reynolds, E. C., Shapira, L. & Zaura, E. 2017. Role of microbial biofilms in the maintenance of oral health and in the development of dental caries and periodontal diseases. Consensus report of group 1 of the Joint EFP/ORCA workshop on the boundaries between caries and periodontal disease. J Clin Periodontol, 44 Suppl 18, S5-s11.
• Sanz, M. & Kornman, K. 2013. Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol, 40 Suppl 14, S164-9.
• Sanz, M. & Teughels, W. 2008. Innovations in non-surgical periodontal therapy: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol, 35, 3-7.
• Sanz, M., Van Winkelhoff, A. J., Herrera, D., Dellemijn-Kippuw, N., Simon, R. & Winkel, E. 2000. Differences in the composition of the subgingival microbiota of two periodontitis populations of different geographical origin. A comparison between Spain and The Netherlands. Eur J Oral Sci, 108, 383-92.
• Schenkein, H. A. & Loos, B. G. 2013. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. J Periodontol, 84, S51-69.
• Seinost, G., Wimmer, G., Skerget, M., Thaller, E., Brodmann, M., Gasser, R., Bratschko, R. O. & Pilger, E. 2005. Periodontal treatment improves endothelial dysfunction in patients with severe periodontitis. Am Heart J, 149, 1050-4.
• Skilton, M. R., Maple-Brown, L. J., Kapellas, K., Celermajer, D. S., Bartold, M., Brown, A., O'dea, K., Slade, G. D. & Jamieson, L. M. 2011. The effect of a periodontal intervention on cardiovascular risk markers in Indigenous Australians with periodontal disease: the PerioCardio study. BMC Public Health, 11, 729.
• Slocum, C., Kramer, C. & Genco, C. A. 2016. Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis. J Intern Med, 280, 114-28.
• Streblow, D. N., Soderberg-Naucler, C., Vieira, J., Smith, P., Wakabyashi, E., Ruchti, F., Mattison, K., Altschuler, Y. & Nelson, J. A. 1999. The human cytomegalovirus chemokine receptor US28 mediates vascular smooth muscle cell migration. Cell, 99, 511-20.
• Tatakis, D. N. & Kumar, P. S. 2005. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am, 49, 491-516, v.
• Taubman, M. A., Kawai, T. & Han, X. 2007. The new concept of periodontal disease pathogenesis requires new and novel therapeutic strategies. J Clin Periodontol, 34, 367-9.
• Teeuw, W. J., Slot, D. E., Susanto, H., Gerdes, V. E., Abbas, F., D'aiuto, F., Kastelein,
J. J. & Loos, B. G. 2014. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol, 41, 70-9.
• Tomas, I., Diz, P., Tobias, A., Scully, C. & Donos, N. 2012. Periodontal health status and bacteraemia from daily oral activities: systematic review/meta-analysis. J Clin Periodontol, 39, 213-28.
• Tonetti, M. S. 2009. Periodontitis and risk for atherosclerosis: an update on intervention trials. J Clin Periodontol, 36 Suppl 10, 15-9.
• Tonetti, M. S., D'aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P. & Deanfield, J. 2007. Treatment of periodontitis and endothelial function. N Engl J Med, 356, 911-20.
• Tonetti, M. S. & Van Dyke, T. E. 2013. Periodontitis and atherosclerotic cardiovascular disease: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Periodontol, 84, S24-9.
• Toregeani, J. F., Nassar, C. A., Nassar, P. O., Toregeani, K. M., Gonzatto, G. K., Vendrame, R., Castilhos, J. S., Rotta, L. S., Reinheimer, A. C., Longoni, A. & Barcella,
M. W. 2016. Evaluation of periodontitis treatment effects on carotid intima-media thickness and expression of laboratory markers related to atherosclerosis. Gen Dent, 64, 55-62.
• Van Strydonck, D. A., Slot, D. E., Van Der Velden, U. & Van Der Weijden, F. 2012. Effect of a chlorhexidine mouthrinse on plaque, gingival inflammation and staining in gingivitis patients: a systematic review. J Clin Periodontol, 39, 1042-55.
• Vidal, F., Figueredo, C. M., Cordovil, I. & Fischer, R. G. 2009. Periodontal therapy reduces plasma levels of interleukin-6, C-reactive protein, and fibrinogen in patients with severe periodontitis and refractory arterial hypertension. J Periodontol, 80, 786-91.
• Wang, Z. & Hoy, W. E. 2010. C-reactive protein: an independent predictor of cardiovascular disease in Aboriginal Australians. Aust N Z J Public Health, 34 Suppl 1, S25-9.
• Weber, C. & Noels, H. 2011. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med, 17, 1410-22.
• Wilson, P. W., D'agostino, R. B., Levy, D., Belanger, A. M., Silbershatz, H. & Kannel,
W. B. 1998. Prediction of coronary heart disease using risk factor categories.
Circulation, 97, 1837-47.
• Yu, Y. H., Chasman, D. I., Buring, J. E., Rose, L. & Ridker, P. M. 2015. Cardiovascular risks associated with incident and prevalent periodontal disease. J Clin Periodontol, 42, 21-8.
• Zeng, X. T., Leng, W. D., Lam, Y. Y., Yan, B. P., Wei, X. M., Weng, H. & Kwong, J. S. 2016. Periodontal disease and carotid atherosclerosis: A meta-analysis of 17,330 participants. Int J Cardiol, 203, 1044-51.
• Zhang, T., Kurita-Ochiai, T., Hashizume, T., Du, Y., Oguchi, S. & Yamamoto, M. 2010. Aggregatibacter actinomycetemcomitans accelerates atherosclerosis with an increase in atherogenic factors in spontaneously hyperlipidemic mice. FEMS Immunol Med Microbiol, 59, 143-51.