Publication: Evaluación de la expresión de marcadores moleculares en tumores queratoquísticos odontogénicos (TQQOS) vs queratoquistes odontogénicos (QQOs) de los maxilares y sus implicaciones pronósticas y/o terapéuticas
Loading...
Official URL
Full text at PDC
Publication Date
2016
Authors
Advisors (or tutors)
Editors
Journal Title
Journal ISSN
Volume Title
Publisher
Citations
Exportar
Abstract
Valorar las diferencias en los niveles de expresión entre los siguientes marcadores moleculares: Ciclina D1, COX-2, Calretinina, MF y MIB 1 (Ki-67), entre casos diagnosticados como TQQOs vs QOOs para valorar si se podrían utilizar en el diagnóstico diferencial de estas lesiones, en el pronóstico y el tratamiento.
- Objetivo específico 1 (OE1): Valorar las posibles diferencias existentes entre ambas lesiones en relación a las variables epidemiológicas de la muestra analizada.
- Objetivo específico 2 (OE2): Evaluar las diferencias entre la tasa de recurrencias del TQQO vs QOO relacionándolas con el tratamiento que recibieron en cada caso.
- Objetivo específico 3 (OE3): Establecer si existen diferencias estadísticamente significativas en la expresión de los marcadores celulares en TQQO vs QOO.
- Objetivo específico 4 (OE4): Evaluar las posibles diferencias de expresión en ambos grupos de lesiones y su posible relación con el tratamiento realizado y su pronóstico.
Description
UCM subjects
Unesco subjects
Keywords
Citation
Agaram, N. P., B. M. Collins, et al. Molecular analysis to demonstrate that odontogenic keratocysts are neoplastic. Arch Pathol Lab Med .2004;128(3): 313-317.
Ahlfors E, Larsson A, Sjögren S. The odontogenic keratocyst: a benign cystic tumor? J Oral Maxillofac Surg 1984; 42(1):10–9.
Andisheh-Tadbir A, Pardis S, Ranjbaran P. Twist expression in dentigerous cyst, odontogenic keratocyst, and ameloblastoma. Oral Maxillofac Surg. 2015;19(1):103-7
Ayoub MS, Baghdadi HM, El-Kholy M. Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors. BMC ClinPathol. 2011;11:4.
Baghei F, Eslami M, Sadri D. Evaluation of Ki-67 Antigen and Protein P53 Expression in Orthokratinized and Parakratinized Odontogenic Keratocyst. Journal of Dentistry, Tehran University of Medical Sciences, Tehran, Iran .2004; 1, No. 2
Barnes L, Eveson JW, Reichart P, Sidransky D. Tumors of the Salivary Glands. En: Pathology and Genetics of the Head and Neck Tumours, Whorld Health Organization, Lyon.2005.p.209.
Barreto DC, Gomez RS, Bale AE, Boson WL, De Marco L. PTCH gene mutations in odontogenic keratocysts. J Dent Res. 2000; 79(6):1418–22.
Bhargava D, Deshpande A, Pogrel MA. Keratocyst Odontogenic Tumour (KCOT) a cyst-to a tumour. Oral Maxillofac Surg. 2012; 16:163–170
Blanas N, Freund B, Schwartz M, Furst IM. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol. 2000; 90(5): 553-8.
Byatnal, A., Natarajan, J., Narayanaswamy, V., & Radhakrishnan, R. Orthokeratinized odontogenic cyst: critical appraisal of a distinct entity. Braz J Oral Scl. 2013; 12(1):71-75.
Chaisuparat R, Yodsanga S, Montaner S, Jham BC. Activation of the Akt/mTOR pathway in dentigerous cysts, odontogenic keratocysts, and ameloblastomas. Oral Surg Oral Med Oral Pathol Oral Radiol. [Research Support, Non-U.S. Gov't]. 2013;116(3):336-42.
Chirapathomsakul D,Sastravaha P, Jansisyanont P. A review of odontogenic keratocysts and the behavior of recurrences. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;101:5-9
Coleman H, Altini M, Ali H, Doglioni C, Favia G, Maiorano E. Use of calretinin in the differential diagnosis of unicystic ameloblastomas. Histopathology [serial on the Internet]. (2001, Apr), [cited December 1, 2015]; 38(4): 312-317. Available from: Academic Search Premier.
De Andrade Santos PP, de Aquino ARL, Barreto AO, de Almeida Freitas R, Galvão HC, de Souza LB. Immunohistochemical expression of nuclear factor κB, matrix metalloproteinase 9, and endoglin (CD105) in odontogenic keratocysts, dentigerous cysts, and radicular cysts. Oral Surg, Oral Med, Oral Pathol, Oral Radiol, Endod. 2011;112(4):476-83.
De Vicente JC, Torre-Iturraspe A, Gutiérrez AM, Lequerica-Fernández P. Immunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions. Med Oral Patol Oral Cir Bucal. 2010;15 (5):709-15.
Dong Q, Pan S, Sun L, Li T. Orthokeratinized odontogenic cyst: a clinicopathologic study of 61 cases. Archives Of Pathology & Laboratory Medicine [serial online]. February 2010;134(2):271-275 5p. Available from: CINAHL with Full Text, Ipswich, MA. Accessed December 8, 2015.
Dos Santos, J. N., Oliveira, G. Q., Vasconcelos, G., Silva C.A, De Souza, R., Gonçalves O. Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors. Journal of Molecular Histology.2009; 40(4): 269-75.
Fortin P, Briend M, Morales S, Alsina A, Solís M. Expresión inmunohistoquímica de PCNA, Ki-67 y ciclina D1 en ameloblastomas multiquísticos. RAOO. 2014; 52(1): 43-9.
Gani F, Mahomed F, Meer S. Evaluation of Ki-67 and cyclin D1 expression in odontogenic keratocysts and orthokeratinised jaw cysts. SADJ. 2012; 67(7): 370-75
Gónzalez-Moles MA, Mosqueda- Tylor A, Delgado-Rodriguez M, Martínez-Mata G, Gil-Montoya JA, Díaz-Franco MA y cols. Analysis of p53 Protein by PAb240, Ki-67 Expression and Human Papillomavirus DNA Detection in Different Types of Odontogenic Keratocyst. Anticancer Res. 2006;(26):175-182
Ram, H., Mohammad, S., Husain, N., Gupta, S., & Kumar, A. Bilateral odontogenic keratocyst of the mandible. J Maxilo Oral Surg. 2014: 13(3); 341-345.
Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science. 1991; 253(5015):49-53.
Jamshidi S, Zargaran M, Baghaei F, Shojaei S, Mahmoodabadi RZ, Dehghan A, et al. An Immunohistochemical Survey to Evaluate the Expression of CD105 and CD34 in Ameloblastoma and Odontogenic Keratocyst. Journal of Dentistry. 2014;15(4):192.
Jones A, Craig G, Franklin C. Range and demographics of odontogenic cysts diagnosed in a UK population over a 30‐year period. Journal Oral Pathol & Med. 2006;35(8):500-7
Jordan R, Speight PM. Current concepts of odontogenic tumours. Mini Symposium: Oral and Maxillofacial surgery. Diagnostic Histopatology. 2009;15(6): 303-310
Kaminagamura E., Almeida J.D, Carvalho Y.R, Franco R.C, Soares F.A, Rocha R.M et al. Keratocyst of the buccal mucosa: case report and immunohistochemical comparative study with sporadic intraosseous keratocystic odontogenic tumor. Oral Surg Oral MedOral Pathol Oral Radiol. 2013;116:387-392
Knudson, A G. Mutation and cancer: statistical study of retinoblastoma. Proceedings of the National Academy of Sciences. 1971; 68( 4): 820-823.
Kramer IR, Toller PA. The use of exfoliative cytology and protein estimations in preoperative diagnosis of odontogenic keratocysts. International J Oral Surg. 1973;2(4):143-51.
Kubota Y, Shirasuna K. Roles of IL-1alfa in the growth of keratocyst odontogenic tumor. Oral Science Int. May 2007: 19-27
Kumamoto H. Molecular alterations in the development and progression of odontogenic tumors. Oral Med Pathol.2010; 14: 121-9
Lane DP. Cancer. P53, guardian of the genome. Nature. 1992;358(6381):15-6.
Leonardi, R., Matthews, J. B., Caltabiano, R., Greco, M., Lombardo, C., Loreto, C. & Lo Muzio, L. MMP‐13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts. Oral Dis.2010;16(8): 795-800.
Li, TJ. The Odontogenic Keratocyst A Cyst, or a Cystic Neoplasm?. J Dental Res 2011; 90 (2): 133-142.
Madras J, Lapointe H . Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour.Tex Dent J .2008;125(5): 446.
Malčić, A., Jukić S, et al. Alterations of FHIT and P53 genes in keratocystic odontogenic tumor, dentigerous and radicular cyst. J Oral Pathol Med. 2008; 37(5): 294-301.
Marimón Torres, M. E., Martínez, C., Herrera Pérez, M., & Álvarez Morejón, F. (2009). Medicina bucal I. La Habana: Editorial de Ciencias Médicas, 165.
Márquez, M. M. Delgado-Azañero Q W., & Ubaqui, V. C. Características radiográficas de los queratoquistes odontogénicos paraqueratinizados del maxilar inferior. Revista Estomatológica Herediana. 2014; 15(2):112.
Mendes RA, Carvalho JFC, Van der Waal I. A comparative immunohistochemical analysis of COX-2, p53, and Ki-67 expression in keratocystic odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111:333-339
Moreira, P. R., Guimarães, M. M., Guimarães, A. L. S., Diniz, M. G., Gomes, C. C., Brito, J. A. R., & Gomez, R. S. Methylation of P16, P21, P27, RB1 and P53 genes in odontogenic keratocysts. J Oral Pathol & Med. 2010; 38(1): 99-103.
Myoung H, Hong SP, Hong SD, Lee J, Lim C, Choung PH et al. Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol. 2001; 91(3): 328-33
Nayak MT, Singh A, Singhvi A, Sharma R. Odontogenic keratocyst: What is in the name?.Journal of Natural Science. 2013; 4(2) : 282-5
Ohki, K., et al. PTC gene mutations and expression of SHH, PTC, SMO, and GLI-1 in odontogenic keratocysts. International J Oral Maxillofac Surg. 2004; 33(6): 584-592.
Ogden, G. R., Kiddie, R. A., Lunny, D. P., & Lane, D. P. Assessment of p53 protein expression in normal, benign, and malignant oral mucosa. J Pathol.1992; 166(4): 389-394.
Oré de La Cruz, J., Barria Angulo, H. y Nuñez Villalva, J. Tratamiento de queratoquiste en mentón con injerto de cresta iliaca. Kiru. 2010; 7(1):38-42.
Philipsen HP. Om keratocyster (kolesteatomer) i kaeberne. Tandlaegebladet. 1956;60(963): 3.
Philipsen HP, Barnes L, Eveson JW, Reichart P, Sidransky D. Keratocyst odontogenic tumour. (2005): 306-7
Pogrel MA, Jordan RCK. Marsupializacion as a definitive treatment for the odontogenic keratocyst. J Oral Maxillofac Surg.2004; 62:651-655
Ramesh, M., Krishnan, R., Chalakkal, P., & Paul, G. Goltz-gorlin syndrome: Case report and literature review. JOMFP. 2015; 19(2):267.
Rodríguez RG, Cossíob P, Parejo P, Carranza E, García A, Castroa D. Síndrome de Gorlin-Goltz: manejo del carcinoma basocelular facial. Rev Esp Cir Oral Maxilof. 2013;3 5(1):23–30
Romero Flores J, Colín Ordaz A. Queratoquiste asociado a síndrome de Gorlin-Goltz. Reporte de un caso. AMCBM Colegio. 2012 ;8 (3): 98-102
Roy, S., & Garg, V. Evaluation of stromal myofibroblasts expression in keratocystic odontogenic tumor and orthokeratinized odontogenic cysts: a comparative study. JOMFP. 2013; 17(2):207.
Sánchez-Legaza E, Sanmartín – Anaya A, Fernández-Freire A. Odontogenic keratocyst. Acta Otorrinolaringol Esp. 2009;60(2):148
Sapp JP, Eversole LR, Wysocki GP. Capítulo 2: Quistes de las regiones orales. En: Patología oral y maxilofacial contemporánea. 2ª Ed.2005. Pag 45-69
Sharif F, Oliver R, Sweet C, Sharif M. Intervenciones para el tratamiento de los tumores queratoquísticos odontogénicos (TQQO, queratoquistes odontogénicos [QQO]) (Revision Cochrane traducida). Cochrane Database of Systematic Reviews. 2010 Issue 9. Art. No.: CD008464. DOI: 10.1002/14651858.CD008464
Shear M. The aggressive nature of the odontogenic keratocyst: it is a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behaviour. Oral Oncol. 2002; 38: 219–26
Shear M, Speight P. Capítulo 3: Odontogenic Keratocyst. En: Cyst of the oral and Maxilofacial Regions. 4 ed. 2007. Pag 6-59
Shear M., Seward G. R. Cysts of the oral regions. John Wright.1992.
Soskolne, W. A., & Shear, M. Observations on the pathogenesis of primordial cysts. British Dental J.1967; 123(7):321.
Sreedhar, G., Raju, M., Metta, K., Manjunath, S., Shetty, S., & Agarwal, R. Immunohistochemical analysis of factors related to apoptosis and cellular proliferation in relation to inflammation in dentigerous and odontogenic keratocyst. Journal of Natural Science, Biology and Medicine.2014; 5(1): 112-115. doi:http://0-dx.doi.org.cisne.sim.ucm.es/10.4103/0976-9668.127300
Stoelinga, P. J. Etiology and pathogenesis of keratocysts. Oral Maxillofac Surg Clinics North Ame. 2003; 15(3): 317-324.
Stoelinga, P. J. The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with Carnoy solution. J Oral Maxillofac Surg. 2005;63(11): 1662-1666.
Stoll, C., Stollenwerk, C., Riediger, D., Mittermayer, C., & Alfer, J. Cytokeratin expression patterns for distinction of odontogenic keratocysts from dentigerous and radicular cysts. J Oral Pathol & Med. 2005;34(9): 558-564.
Sundaragiri, S. K., Chawda, J., Gill, S., Odedra, S., & Parmar, G. Calretinin expression in unicystic ameloblastoma: An aid in differential diagnosis. J Oral Bio. 2010;52(2):164-169.
Thosaporn W, Iamaroon A, Pongsiriwet S, Ng KH. A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and ameloblastoma. Oral Dis. 2004; 10 (1):22-6
Varsha BK, Gharat AL, Nagamalini BR, Jyothsna M, Mothkur ST, Swaminathan U. Evaluation and comparison of expression of p63 in odontogenic keratocyst, solid ameloblastoma and unicystic ameloblastoma. J Oral Maxillofac Pathol 2014;18:223-8.
Vera-Sirera B, Forner-Navarro L, Vera-Sempere F. Differential expression of cyclin d1 in keratin-producing odontogenic cysts. Med Oral Patol Oral Cir Bucal. 2014, doi:10.4317/medoral.20114
Vered M, et al. Myofibroblasts in stroma of odontogenic cysts and tumors can contribute to variations in the biological behavior of lesions. Oral oncology, 2005; 41(10): 1028-1033.
Villarroel M, Porras D, Rodriguez M. Uso del marcador KI-67 en la toma de decisión del tratamiento de tumor odontogénico quístico queratinizante. Presentación de un caso. Acta Odontol Venez. 2012;50;(1)1-5.
Zamorano R, Rocha A, Nuñez B, Espínola MJ, Haito CH, Gónzalez P. Aggressive jaw Ameloblastoma. Report of one case. Rev. Chilena Cir. 2008; (60) : 339-343.
Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004;117(7):927-39.
Younis WH, Hussein AG, Garib BT. Detection of KI-67, BCL-2, terminally apoptotic cells (tunel assay) CD34 and VEGF in ameloblastoma. Europ Scien Journal. 2014;10 (33):284-298.
Wang, J., Zhang, X., Ding, X., Xing, S., Li, H., Zhang, W et al . Cyclooxygenase‑2 expression in keratocystic odontogenic tumour decreased following decompression. Molec Clinical Oncol.2013; 1(6):982-986.
Weber, A. L., Kaneda, T., Scrivani, S. J., & Aziz, S. Jaw: cysts, tumors, and nontumorous lesions. En: Head and neck imaging, 4º Ed. 2003. Pag 930-994.