Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases



Downloads per month over past year

Alkozi, Hanan Awad and Franco, Rafael and Pintor, Jesús (2017) Epigenetics in the Eye: An Overview of the Most Relevant Ocular Diseases. Frontiers in Genetics, 8 . art. 144. ISSN 1663-4365

[thumbnail of Pintor_Epigenetics-FrontiersGenetics-2017.pdf]
Creative Commons Attribution.


Official URL: https://doi.org/10.3389/fgene.2017.00144


Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year after year for non-genetic reasons, namely cataracts, dry eye, and glaucoma. Aging, diet, inflammation, drugs, oxidative stress, seasonal and circadian style-of-live changes are impacting on disease prevalence by epigenetics factors, defined as stable heritable traits that are not explained by changes in DNA sequence. The mini-review will concisely show the data showing epigenetics marks in these diseases and on how knowledge on the epigenetic alterations may guide therapeutic approaches to have a healthy eye.

Item Type:Article
Additional Information:

This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission.

Uncontrolled Keywords:Cataracts, Glaucoma, Dry eye, Keratoconus, Eye diseases
Subjects:Medical sciences > Medicine > Ophtalmology
ID Code:45565
Deposited On:27 Nov 2017 12:13
Last Modified:11 Dec 2017 12:57

Origin of downloads

Repository Staff Only: item control page