Publication: Ensayo clínico aleatorizado comparando una nueva membrana de colágeno reabsorbible no "cross-linked" para regeneración ósea guiada de dehiscencias en implantes. Resultados parciales.
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2016
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Abstract
Objetivo: Comparar los resultados clínicos de una nueva membrana de colágeno reabsorbible, Creos xenoprotect (CXP), frente a la membrana de referencia BioGide (BG) para la regeneración ósea guiada en zonas que requieren implantes y presentan defectos óseos tipo dehiscencias.
Materiales y métodos: Este ensayo clínico aleatorizado controlado incluyó pacientes con dehiscencias tras la colocación del implante para la restauración de una única pieza en la zona estética o de premolares en maxilar o mandíbula. Los implantes se colocaron en dos etapas con carga diferida. El biomaterial de regeneración ósea colocado en la superficie del implante se fijó con la membrana CXP o BG. La salud del tejido blando se comprobó durante el periodo de cicatrización y el tamaño del defecto óseo se midió en la reentradaa los 6 meses tras la colocación del implante.
Resultados: De los 7 pacientes incluidos, 4 fueron tratados con CXP y 3 con BG. Las características de los pacientes no diferían en nada entre ambos grupos. En el grupo CXP, la altura del defecto (DH) en el momento de la inserción del implante era (mean±SD) 4.5 ±1.2mm (n=4). A los 6 meses, en la reentrada, la altura del defecto había disminuido a 1.3 ±1.53mm (n=3). En el grupo BG, la altura del defecto en la inserción del implante era 6 ± 00 mm (n=3), en la reentrada había disminuido a 1.9 ± 1.1mm (n=3). Asumiendo un margen de no inferioridad de 1mm CXP ha sido no inferior a BG. El porcentaje de exposición de membrana fue más alto en la tercera semana en ambos grupos.
Conclusiones: La nueva membrana reabsorbible de colágeno facilita la ganancia de hueso en la colocación de implantes en zonas con dehiscencias. La tendencia observada hacia una mayor ganancia de hueso y un porcentaje menor de exposición de la membrana de CXP comparada con BG debería ser investigada en un futuro.
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Aghaloo, T. L., Moy, P. K. (2007). Which hard <ssue augmenta<on techniques are the most successful in furnishing bony support for implant placement? Interna<onal Journal of Oral & Maxillofacial Implants 22.
Albrektsson, T., Berglundh, T., Lindhe, J. (2003). Karring Th, Lang NP: Clinical Periodontology and Implant Dentistry: Blackwell Munksgaard, a Blackwell Publishing Company Oxford UK;.
Araújo, M. G., Lindhe, J. (2005). Dimensional ridge alterations following tooth extraction. An experimental study in the dog. Journal of clinical periodontology 32:212-218.
Araújo, M. G., Wennström, J. L., Lindhe, J. (2006). Modeling of the buccal and lingual bone walls of fresh extraction sites following implant installation. Clinical oral implants research 17:606-614.
Becker, J., Al-Nawas, B., Klein, M. O., Schliephake, H., Terheyden, H., Schwarz, F. (2009). Use of a new crosslinked collagen membrane for the treatment of dehiscence-type defects at titanium implants: a prospective, randomized-controlled double-blinded clinical multicenter study. Clin Oral Implants Res 20:742-749.
Becker, W., Dahlin, C., Becker, B. E., Lekholm, U., van Steenberghe, D., Higuchi, K. et al. (1994). The use of e- PTFE barrier membranes for bone promotion around titanium implants placed into extraction sockets: a prospective multicenter study. Int J Oral Maxillofac Implants 9:31-40.
Blumenthal, N.M. (1988). The use of collagen membranes to guide regeneration of new connective tissue aiachment in dogs. Journal of Periodontology 59, 830–836.
Blumenthal, N.M. (1993). A clinical comparison of collagen membranes with e-PTFE membranes in the treatment of human mandibular Class II furcation defects. Journal of Periodontology 64, 925–933.
Bozkurt, A., Apel, C., Sellhaus, B., van Neerven, S., Wessing, B., Hilgers, R. D. et al. (2014). Differences in degradation behavior of two non-cross-linked collagen barrier membranes: an in vitro and in vivo study. Clinical Oral Implants Research 25:1403–1411.
Branemark, P. I., Hansson, B. O., Adell, R., Breine, U., Lindstrom, J., Hallen, O. et al. (1977). Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl 16:1-132.
Branemark, P. I., Engstrand, P., Ohrnell, L. O., Grondahl, K., Nilsson, P., Hagberg, K. et al. (1999). Branemark Novum: a new treatment concept for rehabilitation of the edentulous mandible. Preliminary results from a prospective clinical follow-up study. Clinical implant dentistry and related research 1:2-16.
Burkhardt, R., Lang, N. (2010). Role of flap tension in primary wound closure of mucoperiosteal flaps: A prospective cohort study. Clinical oral implants research 21:50-54.
Buser, D., Bragger, U., Lang, N. P., Nyman, S. (1990). Regeneration and enlargement of jaw bone using guided tissue regeneration. Clin Oral Implants Res 1:22-32.
Buser, D., Mericske-Stern, R., Bernard, J. P., Behneke, A., Behneke, N., Hirt, H. P. et al. (1997). Long-term evaluation of non-submerged ITI implants. Part 1: 8-year life table analysis of a prospective multi-center study with 2359 implants. Clin Oral Implants Res 8:161-172.
Caffesse, R.G., Nasjleti, C.E., Morrison, E.C. & Sanchez, R. (1994). Guided tissue regeneration: comparison of bioab- sorbable and non-bioabsorbable membranes. Histologic and histometric study in dogs. Journal of Periodontology 65, 583–591.
Camelo, M., Nevins, M., Schenk, R. et al. (1998). Clinical radio- graphic, and histologic evaluation of human periodontal defects treated with Bio-Oss® and Bio-Gide. International Journal of Periodontics and Restorative Dentistry 18, 321–331.
Carpio, L., Loza, J., Lynch, S., Genco, R. (2000). Guided bone regeneration around endosseous implants with anorganic bovine bone mineral. A randomized controlled trial comparing bioabsorbable versus nonresorbable barriers. Journal of periodontology 71:1743-1749.
Caton, J., Greenstein, G. & Zappa, U. (1994). Synthetic bioab- sorbable barrier for regeneration in human periodontal defects. Journal of Periodontology 65, 1037–1045.
Cortellini, P. & Bowers, G.M. (1995). Periodontal regeneration at intrabony defects: an evidence-based treatment approach. International Journal of Periodontics and Restorative Dentistry 15, 128–145.
Cortellini, P. & Toneo, M.S. (2001). Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. Journal of Periodontology 72, 559–569.
Dahlin, C., Linde, A., Goilow, J., Nyman, S. (1988). Healing of bone defects by guided tissue regeneration. Plastic and reconstructive surgery 81:672-676.
den Hartog, L., Slater, J. J., Vissink, A., Meijer, H. J., Raghoebar, G. M. (2008). Treatment outcome of immediate, early and conventional single-tooth implants in the aesthetic zone: a systematic review to survival, bone level, soq-tissue, aesthetics and patient satisfaction. J Clin Periodontol 35:1073-1086.
Donos, N., Mardas, N., Chadha, V. (2008). Clinical outcomes of implants following lateral bone augmentation: systematic assessment of available options (barrier membranes, bone graqs, split osteotomy). Journal of clinical periodontology 35:173-202.
Friedmann, A., Gissel, K., Soudan, M., Kleber, B. M., Pitaru, S., Dietrich, T. (2011). Randomized controlled trial on lateral augmentation using two collagen membranes: morphometric results on mineralized tissue compound. J Clin Periodontol 38:677-685.
Garber, D. A., Belser, U. C. (1995). Restoration-driven implant placement with restoration-generated site development. Compendium of continuing education in dentistry (Jamesburg, NJ: 1995) 16:796, 798-802, 804.
Goilow, J., Nyman, S., Karring, T., Lindhe, J. (1984). New aiachment formation as the result of controlled tissue regeneration. Journal of clinical periodontology 11:494-503.
Goilow, J., Laurell, L., Lundgren, D. et al. (1994). Periodontal tissue response to a new bioresorbable guided tissue regen- eration device. A longitudinal study in monkeys. International Journal of Periodontics and Restorative Dentistry 14, 437–449.
Hammerle, C. H., Lang, N. P. (2001). Single stage surgery combining transmucosal implant placement with guided bone regeneration and bioresorbable materials. Clin Oral Implants Res 12:9-18.
Hof, M., Pommer, B., Strbac, G. D., Suto, D., Watzek, G., Zechner, W. (2013). Esthetic evaluation of singletooth implants in the anterior maxilla following autologous bone augmentation. Clin Oral Implants Res 24:88–93.
Hof, M., Pommer, B., Ambros, H., Jesch, P., Vogl, S., Zechner, W. (2015). Does Timing of Implant Placement Affect Implant Therapy Outcome in the Aesthetic Zone? A Clinical, Radiological, Aesthetic, and Patient- Based Evaluation. Clinical implant dentistry and related research 17:1188–1199.
Hugoson, A., Ravald, N., Fornell, J. et al. (1995). Treatment of class II furcation involvements in humans with bioresorba- ble and nonresorbable guided tissue regeneration barriers. A randomized multicenter study. Journal of Periodontology 66, 624–634.
Hürzeler, M.B., Quinones, C.R., Caffesse, R.G., Schupback, P. & Morrison, E.C. (1997). Guided periodontal tissue regen- eration in interproximal intrabony defects following treat- ment with a synthetic bioabsorbable barrier. Journal of Periodontology 68, 489–497.
Jung, R. E., Glauser, R., Scharer, P., Hammerle, C. H., Sailer, H. F., Weber, F. E. (2003). Effect of rhBMP-2 on guided bone regeneration in humans. Clin Oral Implants Res 14:556-568.
Jung, R. E., Halg, G. A., Thoma, D. S., Hammerle, C. H. (2009). A randomized, controlled clinical trial to evaluate a new membrane for guided bone regeneration around dental implants. Clin Oral Implants Res 20:162-168.
Khzam, N., Arora, H., Kim, P., Fisher, A., Maiheos, N., Ivanovski, S. (2015). A Systematic Review of Soq Tissue Alterations and Aesthetic Outcomes Following Immediate Implant Placement and Restoration of Single Implants in the Anterior Maxilla. Journal of periodontology 86:1321-1330.
Lang, N. P., Hammerle, C. H., Bragger, U., Lehmann, B., Nyman, S. R. (1994). Guided tissue regeneration in jawbone defects prior to implant placement. Clin Oral Implants Res 5:92-97.
Laurell, L., Falk, H., Fornell, J., Johard, G. & Goilow, J. (1994). Clinical use of a bioresorbable matrix barrier in guided tis- sue regeneration therapy. Case series. Journal of Periodontology 65, 967–975.
Lekholm, U., Gunne, J., Henry, P., Higuchi, K., Linden, U., Bergstrom, C. et al. (1999). Survival of the Branemark implant in partially edentulous jaws: a 10-year prospective multicenter study. Int J Oral Maxillofac Implants 14:639-645.
Machtei, E. E. (2001). The effect of membrane exposure on the outcome of regenerative procedures in humans: a meta-analysis. Journal of periodontology 72:512-516.
Magnusson, I., Batich, C. & Collins, B.R. (1988). New aiachment formation following controlled tissue regeneration using biodegradable membranes. Journal of Periodontology 59, 1–6.
Mellonig, J.T. (2000). Human histologic evaluation of a bovine- derived bone xenograq in the treatment of periodontal osse- ous defects. International Journal of Periodontics and Restorative Dentistry 20, 18–29.
Mir-Mari, J., Wui, H., Jung, R. E., Hammerle, C. H., Benic, G. I. (2016). Influence of blinded wound closure on the volume stability of different GBR materials: an in vitro cone-beam computed tomographic examination. Clin Oral Implants Res 27:258-265.
Moses, O., Pitaru, S., Artzi, Z., Nemcovsky, C. E. (2005). Healing of dehiscence-type defects in implants placed together with different barrier membranes: a comparative clinical study. Clin Oral Implants Res 16:210-219.
Nemcovsky, C. E., Artzi, Z. (2002). Comparative study of buccal dehiscence defects in immediate, delayed, and late maxillary implant placement with collagen membranes: clinical healing between placement and second-stage surgery. Journal of periodontology 73:754-761.
Nisand, D., Picard, N., Rocchieia, I. (2015). Short implants compared to implants in vertically augmented bone: a systematic review. Clin Oral Implants Res 26:170–179.
Nyman, S., Karring, T. (1979). Regeneration of surgically removed buccal alveolar bone in dogs. Journal of periodontal research 14:86-92
Paul, B.F., Mellonig, J.T., Towle, H.J. & Gray, J.L. (1992). The use of a collagen barrier to enhance healing in human periodon- tal furcation defects. International Journal of Periodontics and Restorative Dentistry 12, 123–131.
Pitaru, S., Tal, H., Soldinger, M., Grosskopf, A. & Noff, M. (1988). Partial regeneration of periodontal tissues using col- lagen barriers. Initial observations in the canine. Journal of Periodontology 59, 380–386.
Pjetursson, B. E., Thoma, D., Jung, R., Zwahlen, M., Zembic, A. (2012). A systematic review of the survival and complication rates of implant-supported fixed dental prostheses (FDPs) aqer a mean observation period of at least 5 years. Clinical Oral Implants Research 23:22-38.
Polson, A.M., Southard, G.L., Dunn, R.L. et al. (1995a). Periodontal healing aqer guided tissue regeneration with Atrisorb barriers in beagle dogs. International Journal of Periodontics and Restorative Dentistry 15, 574–589.
Sanz, M., Vignoleo, F., (2015). Key aspects on the use of bone substitutes for bone regeneration of edentulous ridges. Dental Materials 31, 640-647.
Sanz-Sanchez, I., Ortiz-Vigon, A., Sanz-Martin, I., Figuero, E., Sanz, M. (2015). Effectiveness of Lateral Bone Augmentation on the Alveolar Crest Dimension: A Systematic Review and Meta-analysis. J Dent Res 94:S128-S142.
Sculean, A., Donos, N., Chiantella, G.C. et al. (1999a). GTR with bioresorbable membranes in the treatment of intrabony defects: a clinical and histologic study. International Journal of Periodontics and Restorative Dentistry 19, 501–509.
Schropp, L., Wenzel, A., Kostopoulos, L., Karring, T. (2003). Bone healing and soq tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study. Int J Periodontics Restorative Dent 23:313-323.
Schulz, K. F., Altman, D. G., Moher, D. (2010). CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Intern Med 152:726-732.
Simion, M., Baldoni, M., Rassi, P., Zaffe, D. (1994). A comparative study of the effectiveness of e-PTFE membranes with and without early exposure during the healing period. International Journal of Periodontics & Restorative Dentistry 14.
Slade, G. D. (1997). Derivation and validation of a short-form oral health impact profile. Community Dent Oral Epidemiol 25:284-290.
Schwarz F, Rothamel D, Herten M, Sager M, Ferrari D, Becker J. Immunohistochemical characterization of guided bone regeneration at dehiscence-type defect using different barrier membranes: an experimental study in dogs. Clin. Oral Impl. Res. 19, 2008; 402–415
Tal, H., Kozlovsky, A., Artzi, Z., Nemcovsky, C. E., Moses, O. (2008). Long-term bio-degradation of crosslinked and non-cross-linked collagen barriers in human guided bone regeneration. Clin Oral Implants Res 19:295-302.
Tanner, M.G., Solt, C.W. & Vuddhakanok, S. (1988). An evalua- tion of new aiachment formation using a microfibrillar col- lagen barrier. Journal of Periodontology 59, 524–530.
Tatakis, D.N., Promsudthi, A. & Wikesjö, U.M.E. (1999). Devices for periodontal regeneration. Periodontology 2000 19, 59–73.
Toneo, M., Cortellini, P., Suvan, J.E. et al. (1998). Generalizability of the added benefits of guided tissue regeneration in the treatment of deep intrabony defects. Evaluation in a multi- center randomized controlled clinical trial. Journal of Periodontology 69, 1183–1192.
Urban, I. A., Lozada, J. L., Wessing, B., Suarez-Lopez Del Amo, F., Wang, H. L. (2016). Vertical Bone Graqing and Periosteal Vertical Mairess Suture for the Fixation of Resorbable Membranes and Stabilization of Particulate Graqs in Horizontal Guided Bone Regeneration to Achieve More Predictable Results: A Technical Report. Int J Periodontics Restorative Dent 36:153-159.
Wang, H., O’Neal, R., Thomas, C., Shyr, Y. & MacNeil, R. (1994). Evaluation of an absorbable collagen membrane in treating Class II furcation defects. Journal of Periodontology 65, 1029–1036.
Wang, H. L., Misch, C., Neiva, R. F. (2004). "Sandwich" bone augmentation technique: rationale and report of pilot cases. Int J Periodontics Restorative Dent 24:232-245.
Wessing, B., Emmerich, M., Bozkurt, A. (2016). Horizontal Ridge Augmentation with a Novel Resorbable Collagen Membrane: A Retrospective Analysis of 36 Consecutive Patients. Int J Periodontics Restorative Dent 36:179-187.
Zitzmann, N. U., Naef, R., Scharer, P. (1997). Resorbable versus nonresorbable membranes in combination with Bio-Oss for guided bone regeneration. Int J Oral Maxillofac Implants 12:844-852.