Publication: Análisis de las capacidades cognitivas, biomarcadores vasculares y APOE4 en deterioro cognitivo leve y la enfermedad de Alzheimer en panameños adultos
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2018-03-05
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Universidad Complutense de Madrid
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Abstract
Múltiples investigaciones han evidenciado que la patología vascular, el alelo 4 del gen de la apolipoproteína E y la inflamación son biomarcadores de la enfermedad de Alzheimer (EA). En Panamá, los factores de riesgo vasculares y el acelerado envejecimiento poblacional, generan la necesidad de investigar marcadores en deterioro cognitivo leve (DCL) y EA. Identificar los cambios cerebrales en etapas prodrómicas pudiera incidir positivamente en la intervención y en el retraso de la aparición de los síntomas. En países en vías de desarrollo como Panamá se busca estudiar marcadores de DCL/EA que sean sensibles, costo-eficientes, no invasivos y que se puedan utilizar en contextos clínicos y de atención primaria. El objetivo principal fue determinar si en los adultos mayores, con deterioro cognitivo leve y enfermedad de Alzheimer panameños, los biomarcadores vasculares y ApoΕ4 están asociados a las funciones cognitivas. Esta investigación es pionera en Panamá y una de las únicas de su tipo en Latinoamérica...
Research has established that vascular pathology, genetic markers such as Apolipoprotein E allele ε4 and inflammation are risk factors for the progression to Alzheimeŕs Disease (AD). In Panama, vascular risk factors and an increase in aging population, generate the need to investigate biomarkers related to mild cognitive impairment (MCI) and AD. Diagnosing brain changes in a prodromal phase, is key to improving intervention mechanisms and to delay the expression of symptoms. In developing countries like Panama, research is seeking to find specific, sensitive, non-invasive, cost-efficient methods that could be used in primary care and in a clinical context. The main objective of this study was to determine if in healthy controls, MCI and AD Panamanians, vascular biomarkers and ApoΕ4 are associated with cognitive function. To our knowledge this is the first study in Panama and one of the only ones in Latin America to study the association between these variables...
Research has established that vascular pathology, genetic markers such as Apolipoprotein E allele ε4 and inflammation are risk factors for the progression to Alzheimeŕs Disease (AD). In Panama, vascular risk factors and an increase in aging population, generate the need to investigate biomarkers related to mild cognitive impairment (MCI) and AD. Diagnosing brain changes in a prodromal phase, is key to improving intervention mechanisms and to delay the expression of symptoms. In developing countries like Panama, research is seeking to find specific, sensitive, non-invasive, cost-efficient methods that could be used in primary care and in a clinical context. The main objective of this study was to determine if in healthy controls, MCI and AD Panamanians, vascular biomarkers and ApoΕ4 are associated with cognitive function. To our knowledge this is the first study in Panama and one of the only ones in Latin America to study the association between these variables...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Psicología, Departamento de Psicología Básica II (Procesos Cognitivos), leída el 03-07-2017